Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations

MA Tsadok, CA Jackevicius, E Rahme, V Essebag… - CMAJ, 2011 - Can Med Assoc
Background: Amiodarone is associated with dysfunction of the thyroid. Concerns have
arisen regarding the potential for adverse effects with generic formulations of amiodarone …

Amiodarone‐induced thyroid dysfunction associated with cumulative dose

ML Bouvy, ER Heerdink, AW Hoes… - … and drug safety, 2002 - Wiley Online Library
Purpose To obtain risk estimates of thyroid disorder in patients starting amiodarone.
Methods We followed a cohort of 5522 patients with a first prescription for an anti‐arrhythmic …

Determinants and outcome of amiodarone‐associated thyroid dysfunction

S Ahmed, IC Van Gelder, ACP Wiesfeld… - Clinical …, 2011 - Wiley Online Library
Objective Amiodarone is frequently associated with thyroid dysfunction. Identifying
predictors for amiodarone‐associated thyroid dysfunction and assessing treatment outcome …

Time‐to‐onset analysis of amiodarone‐associated thyroid dysfunction

S Kinoshita, K Hosomi, S Yokoyama… - Journal of Clinical …, 2020 - Wiley Online Library
What is known and objective Amiodarone (AMD) treatment is associated with a number of
significant adverse effects including thyroid dysfunction. However, the relationship between …

Incidence of thyroid dysfunction following initiation of amiodarone treatment in patients with and without heart failure: a nationwide cohort study

SA Ali, M Ersbøll, NE Vinding, JH Butt, R Rørth… - Europace, 2023 - academic.oup.com
Aims Thyroid dysfunction is considered the most frequent complication to amiodarone
treatment, but data on its occurrence outside clinical trials are sparse. The present study …

[HTML][HTML] Thyroid dysfunction under amiodarone in patients with and without congenital heart disease: results of a nationwide analysis

AJ Fischer, D Enders, L Eckardt, J Köbe… - Journal of Clinical …, 2022 - mdpi.com
Background: Amiodarone has a profound adverse toxicity profile. Large population-based
analyses quantifying the risk of thyroid dysfunction (TD) in adults with and without congenital …

Evaluation and treatment of amiodarone-induced thyroid disorders

D Ylli, L Wartofsky, KD Burman - The Journal of Clinical …, 2021 - academic.oup.com
Amiodarone is a class III antiarrhythmic drug containing 37% iodine by weight, with a
structure similar to that of thyroid hormones. Deiodination of amiodarone releases large …

Amiodarone-induced thyroid dysfunction in Taiwan: a retrospective cohort study

CJ Huang, PJ Chen, JW Chang, DF Huang… - International journal of …, 2014 - Springer
Background The incidence and risk factors of amiodarone-induced thyroid dysfunction are
variable in the literature. Objective The aim of this study was to investigate the clinical and …

[HTML][HTML] Risk factors for amiodarone-induced thyroid dysfunction in Japan

S Kinoshita, T Hayashi, K Wada, M Yamato… - Journal of …, 2016 - Elsevier
Background Amiodarone is associated with a number of significant adverse effects,
including elevated transaminase levels, pulmonary fibrosis, arrhythmia, and thyroid …

Thyroid function abnormalities during amiodarone therapy for persistent atrial fibrillation

EL Batcher, XC Tang, BN Singh, SN Singh… - The American journal of …, 2007 - Elsevier
BACKGROUND: Many patients receiving amiodarone therapy are male. The long-term risk
for amiodarone-induced thyroid dysfunction in these patients has not been systematically …