Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

…, M Kogevinas, L Chatzi, C Allard, L Bouchard… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy

L Bouchard, S Thibault, SP Guay, M Santure… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE To verify whether the leptin gene epigenetic (DNA methylation) profile is altered
in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH …

[PDF][PDF] Epigenomic profiling reveals DNA-methylation changes associated with major psychosis

…, T Khare, S Yazdanpanah, L Bouchard… - The American Journal of …, 2008 - cell.com
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …

DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1

…, J Mathieu, C Gagnon, L Bouchard - Neurology …, 2019 - AAN Enterprises
Objective To assess the effects of dystrophia myotonica protein kinase (DMPK) DNA
methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic …

[HTML][HTML] Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

L Bouchard, R Rabasa-Lhoret, M Faraj… - The American journal of …, 2010 - Elsevier
Background: Caloric restriction is recommended for the treatment of obesity, but it is generally
characterized by large interindividual variability in responses. The factors affecting the …

Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1

…, S Guauque-Olarte, P Pibarot, L Bouchard… - Circulation, 2016 - Am Heart Assoc
Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …

Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases

…, D Gaudet, MF Hivert, D Brisson, L Bouchard - Epigenetics, 2013 - Taylor & Francis
Offspring exposed to gestational diabetes mellitus (GDM) have an increased risk for chronic
diseases, and one promising mechanism for fetal metabolic programming is epigenetics. …

[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight

…, JJ Hottenga, C Allard, DJ Berry, L Bouchard… - Jama, 2016 - jamanetwork.com
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …

Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration

L Bouchard, MF Hivert, SP Guay, J St-Pierre… - Diabetes, 2012 - Am Diabetes Assoc
<p>Growing evidence suggests that epigenetic profile changes occurring during fetal
development in response to in utero environment variations could be one of the mechanisms …

Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an …

…, S Ring, G Woodward, L Bouchard… - Environmental …, 2015 - ehp.niehs.nih.gov
Background: Prenatal exposure to maternal cigarette smoking (prenatal smoke exposure)
had been associated with altered DNA methylation (DNAm) at birth. Objective: We examined …