Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
…, M Kogevinas, L Chatzi, C Allard, L Bouchard… - Nature …, 2019 - nature.com
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Leptin gene epigenetic adaptation to impaired glucose metabolism during pregnancy
L Bouchard, S Thibault, SP Guay, M Santure… - Diabetes …, 2010 - Am Diabetes Assoc
OBJECTIVE To verify whether the leptin gene epigenetic (DNA methylation) profile is altered
in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH …
in the offspring of mothers with gestational impaired glucose tolerance (IGT). RESEARCH …
[PDF][PDF] Epigenomic profiling reveals DNA-methylation changes associated with major psychosis
…, T Khare, S Yazdanpanah, L Bouchard… - The American Journal of …, 2008 - cell.com
Epigenetic misregulation is consistent with various non-Mendelian features of schizophrenia
and bipolar disorder. To date, however, few studies have investigated the role of DNA …
and bipolar disorder. To date, however, few studies have investigated the role of DNA …
DMPK gene DNA methylation levels are associated with muscular and respiratory profiles in DM1
Objective To assess the effects of dystrophia myotonica protein kinase (DMPK) DNA
methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic …
methylation (DNAme) epivariation on muscular and respiratory profiles in patients with myotonic …
[HTML][HTML] Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction
L Bouchard, R Rabasa-Lhoret, M Faraj… - The American journal of …, 2010 - Elsevier
Background: Caloric restriction is recommended for the treatment of obesity, but it is generally
characterized by large interindividual variability in responses. The factors affecting the …
characterized by large interindividual variability in responses. The factors affecting the …
Altered DNA Methylation of Long Noncoding RNA H19 in Calcific Aortic Valve Disease Promotes Mineralization by Silencing NOTCH1
…, S Guauque-Olarte, P Pibarot, L Bouchard… - Circulation, 2016 - Am Heart Assoc
Background: Calcific aortic valve disease is characterized by an abnormal mineralization of
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
the aortic valve. Osteogenic activity in the aortic valve is under the control of NOTCH1, which …
Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases
…, D Gaudet, MF Hivert, D Brisson, L Bouchard - Epigenetics, 2013 - Taylor & Francis
Offspring exposed to gestational diabetes mellitus (GDM) have an increased risk for chronic
diseases, and one promising mechanism for fetal metabolic programming is epigenetics. …
diseases, and one promising mechanism for fetal metabolic programming is epigenetics. …
[HTML][HTML] Genetic evidence for causal relationships between maternal obesity-related traits and birth weight
…, JJ Hottenga, C Allard, DJ Berry, L Bouchard… - Jama, 2016 - jamanetwork.com
Importance Neonates born to overweight or obese women are larger and at higher risk of
birth complications. Many maternal obesity-related traits are observationally associated with …
birth complications. Many maternal obesity-related traits are observationally associated with …
Placental adiponectin gene DNA methylation levels are associated with mothers' blood glucose concentration
L Bouchard, MF Hivert, SP Guay, J St-Pierre… - Diabetes, 2012 - Am Diabetes Assoc
<p>Growing evidence suggests that epigenetic profile changes occurring during fetal
development in response to in utero environment variations could be one of the mechanisms …
development in response to in utero environment variations could be one of the mechanisms …
Prenatal exposure to maternal cigarette smoking and DNA methylation: epigenome-wide association in a discovery sample of adolescents and replication in an …
…, S Ring, G Woodward, L Bouchard… - Environmental …, 2015 - ehp.niehs.nih.gov
Background: Prenatal exposure to maternal cigarette smoking (prenatal smoke exposure)
had been associated with altered DNA methylation (DNAm) at birth. Objective: We examined …
had been associated with altered DNA methylation (DNAm) at birth. Objective: We examined …