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Protein misassembly into aggregate structures, including cross-β-sheet amyloid fibrils, is
linked to diseases characterized by the degeneration of post-mitotic tissue. While amyloid fibril …

The AP-1 adaptor complex is associated with the TGN, where it links selected membrane
proteins to the clathrin lattice, enabling these proteins to be concentrated in clathrin-coated …

Background: Studies of planned home births attended by registered midwives have been
limited by incomplete data, nonrepresentative sampling, inadequate statistical power and the …

Lysosomes are found in all eukaryotic cell types, and function as organelles specialised in
protein degradation. A series of hydrolases packaged within the lysosomes are able to …

There are two clathrin-coated vesicle adaptor complexes in the cell, one associated with the
plasma membrane and one associated with the TGN. The subunit composition of the …

Amyloid diseases like Alzheimer's disease and familial amyloidosis of Finnish type (FAF) stem
from endoproteolytic cleavage of a precursor protein to generate amyloidogenic peptides …

Familial amyloidosis of Finnish type (FAF) is a systemic amyloid disease associated with the
deposition of proteolytic fragments of mutant (D187N/Y) plasma gelsolin. We report a …

The lytic proteins mediating target cell killing are stored in the lysosomes of activated cytotoxic
T lymphocytes (CTL) and are secreted upon recognition of a target cell. These secretory …

Amyloid diseases occur when native or mutant polypeptides misfold and aggregate to form
deposits in the extracellular space. There are at least 20 proteins associated with amyloid …