The utility of the disposition index as a measure of β‐cell compensatory capacity rests on the
established hyperbolic relationship between its component insulin secretion and sensitivity …

OBJECTIVE To determine in Canadian children aged <18 years the 1) incidence of type 2
diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 …

Maternally synthesized RNAs program early embryonic development in many animals. These
RNAs are degraded rapidly by the midblastula transition (MBT), allowing genetic control of …

Background: The delivery of excess maternal nutrients to the fetus is known to increase the
risk of macrosomia, even among infants of women without gestational diabetes mellitus. With …

Objective. To assess the effect of combined diazoxide-metformin therapy in obese adolescents
treated for craniopharyngioma. Design. A prospective open-label 6-month pilot treatment …

Background and Objectives Turner syndrome ( TS ) confers increased lifetime risk of type 2
diabetes mellitus and cardiovascular disease. We compared cardiometabolic risk factors and …

Context Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by endocrine
and neuropsychiatric problems including hyperphagia, anxiousness, and distress. Intranasal …

Background Disease severity in paediatric obesity is usually defined using the body-mass
index (BMI). Although informative at the population level, its usefulness on an individual level …

Background With increased rates of obesity and insulin resistance in youth, development of
postprandial dyslipidemia, an important cardiovascular disease risk factor, is a concern. …

OBJECTIVE The continuum of maternal glycemia in pregnancy shows continuous
associations with both 1) neonatal birth weight at delivery and 2) subsequent adiposity later in …