ELEVATED BLOOD PRESSURE IS ASSOCIATED WITH an increased risk of cardiovascular
illness and death. Efforts to reduce that risk have led to recommendations for a wide array of …

Over the past decade, national and international guidelines have proposed beta-blockers to
be used on an equal footing with diuretics for initial therapy of hypertension. This preferred …

Randomized controlled trials have concluded that the cardiovascular outcome of first-step
treatment of hypertension with traditional vasoconstricting beta-blockers is inferior to …

Elevated blood pressure is associated with an increased risk of cardiovascular illness and
death. Efforts to reduce that risk have led to recommendations for a wide array of nondrug …

Objective.—To review the scientific evidence concerning the safety and efficacy of various
antihypertensive therapies used as first-line agents and evaluated in terms of major disease …

Although most guidelines committees historically recommended initial diuretics and/or β
blockers for uncomplicated hypertension, clinical trial outcomes analyzed in the last 5 to 7 …

Hypertension is a risk factor for myocardial infarction (MI), stroke, and heart failure and
precedes heart failure in 91% of cases. This becomes even more important considering that …

National guidelines recommend β‐blockers as second step agents after diuretic therapy in
patients without compelling indications despite little clinical trial evidence of cardiovascular …

The present review scrutinizes the recommendations of many guidelines to use β-blockers
and diuretics as first-line therapy in hypertension. These recommendations were ostensibly …

OBJECTIVE: To review the existing data on the use of diuretics or beta-blockers as first-line
therapy for the treatment of mild to moderate hypertension, and to examine the issues …