User profiles for Jacques Turgeon
 | Jacques TurgeonMontreal Verified email at umontreal.ca Cited by 9301 |
Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors
BA Hamelin, J Turgeon - Trends in pharmacological sciences, 1998 - cell.com
… In this review, Bettina Hamelin and Jacques Turgeon discuss how specific physico-chemical
and pharmacological properties (first-pass effect or carrier-mediated uptake) confer …
and pharmacological properties (first-pass effect or carrier-mediated uptake) confer …
A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease
…, C Pharand, E Schampaert, J Turgeon… - European heart …, 2007 - academic.oup.com
Aims We sought to compare the results obtained from six major platelet function tests in the
assessment of the prevalence of aspirin resistance in patients with stable coronary artery …
assessment of the prevalence of aspirin resistance in patients with stable coronary artery …
Prevalence and risk of potential cytochrome p450–mediated drug-drug interactions in older hospitalized patients with polypharmacy
…, J Roy, J Turgeon… - Annals of …, 2013 - journals.sagepub.com
BACKGROUND As rates of polypharmacy rise and medication regimens become more
complex, the risk of potential cytochrome P450 (CYP)–mediated drug-drug interactions (DDIs) is …
complex, the risk of potential cytochrome P450 (CYP)–mediated drug-drug interactions (DDIs) is …
Influence of CYP2D6 activity on the disposition and cardiovascular toxicity of the antidepressant agent venlafaxine in humans
…, G O'Hara, J LeBlanc, J Turgeon - Pharmacogenetics …, 1999 - journals.lww.com
According to in-vitro studies with microsomes from human livers and from yeast expression
systems with high CYP2D6 activity, the major oxidation pathway of venlafaxine is catalysed …
systems with high CYP2D6 activity, the major oxidation pathway of venlafaxine is catalysed …
Domperidone should not be considered a no-risk alternative to cisapride in the treatment of gastrointestinal motility disorders
…, G Rousseau, P Daleau, R Cardinal, J Turgeon - Circulation, 2000 - Am Heart Assoc
Background—Several cases of QT prolongation and ventricular tachyarrhythmia have been
reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but …
reported with domperidone, a gastrokinetic and antiemetic agent available worldwide but …
The ATP-binding cassette transporters and their implication in drug disposition: a special look at the heart
L Couture, JA Nash, J Turgeon - Pharmacological reviews, 2006 - ASPET
The passage of drugs across cell membranes dictates their absorption, distribution, metabolism,
and excretion. This process is determined by several factors including the molecular …
and excretion. This process is determined by several factors including the molecular …
Mechanisms of CYP450 inhibition: understanding drug-drug interactions due to mechanism-based inhibition in clinical practice
…, MJ Arwood, L Darakjian, P Dow, J Turgeon… - Pharmaceutics, 2020 - mdpi.com
In an ageing society, polypharmacy has become a major public health and economic issue.
Overuse of medications, especially in patients with chronic diseases, carries major health …
Overuse of medications, especially in patients with chronic diseases, carries major health …
Effect of a low-glycaemic index–low-fat–high protein diet on the atherogenic metabolic risk profile of abdominally obese men
JG Dumesnil, J Turgeon, A Tremblay… - British Journal of …, 2001 - cambridge.org
It has been suggested that the current dietary recommendations (low-fat–high-carbohydrate
diet) may promote the intake of sugar and highly refined starches which could have adverse …
diet) may promote the intake of sugar and highly refined starches which could have adverse …
Significant interaction between the nonprescription antihistamine diphenhydramine and the CYP2D6 substrate metoprolol in healthy men with high or low CYP2D6 …
…, J Allaire, J Dumesnil, J Turgeon - Clinical …, 2000 - Wiley Online Library
The prototype “classic” over‐the‐counter antihistamine diphenhydramine was shown to interact
with the polymorphic P450 enzyme CYP2D6. This project was undertaken to investigate (…
with the polymorphic P450 enzyme CYP2D6. This project was undertaken to investigate (…
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition
Significant intra- and interindividual variability has been observed in response to use of
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by high …
pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by high …