User profiles for Fred W. Keeley

Fred W Keeley

Senior Scientist Emeritus, Research Institute of the Hospital for Sick Children
Verified email at sickkids.ca
Cited by 11648

[HTML][HTML] Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective

LD Muiznieks, FW Keeley - Biochimica et Biophysica Acta (BBA)-Molecular …, 2013 - Elsevier
The extracellular matrix is an integral and dynamic component of all tissues. Macromolecular
compositions and structural architectures of the matrix are tissue-specific and typically are …

Durability of regenerated articular cartilage produced by free autogenous periosteal grafts in major full-thickness defects in joint surfaces under the influence of …

SW O'Driscoll, FW Keeley, RB Salter - JBJS, 1988 - journals.lww.com
An autogenous graft of tibial periosteum was sutured (with its cambium layer facing into the
joint) to the base of a five by ten-millimeter full-thickness defect in the patellar groove of each …

Adaptations of carotid arteries of young and mature rabbits to reduced carotid blood flow

…, MP Bendeck, FW Keeley - American Journal of …, 1989 - journals.physiology.org
… BENDECK, AND FRED W. KEELEY. Adaptations of carotid arteries of young and mature
rabbits to … PALLIE, W. Embryology of the human arterial system (arteriogenesis). In: Structure …

[PDF][PDF] Proline and glycine control protein self-organization into elastomeric or amyloid fibrils

S Rauscher, S Baud, M Miao, FW Keeley, R Pomes - Structure, 2006 - cell.com
Elastin provides extensible tissues, including arteries and skin, with the propensity for elastic
recoil, whereas amyloid fibrils are associated with tissue-degenerative diseases, such as …

Recombinant human elastin polypeptides self‐assemble into biomaterials with elastin‐like properties

…, AJ Bailey, KA Woodhouse, FW Keeley - Biopolymers …, 2003 - Wiley Online Library
Processes involving self‐assembly of monomeric units into organized polymeric arrays are
currently the subject of much attention, particularly in the areas of nanotechnology and …

Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis.

BH Strauss, RJ Chisholm, FW Keeley… - Circulation …, 1994 - Am Heart Assoc
Remodeling of the vessel wall after balloon angioplasty injury is incompletely understood,
and in particular, the role of extracellular matrix synthesis in restenosis has received little …

Elastin as a self–organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self–assembly of …

FW Keeley, CM Bellingham… - … Transactions of the …, 2002 - royalsocietypublishing.org
Elastin is the major extracellular matrix protein of large arteries such as the aorta, imparting
characteristics of extensibility and elastic recoil. Once laid down in tissues, polymeric elastin …

Coacervation of tropoelastin

GC Yeo, FW Keeley, AS Weiss - Advances in colloid and interface science, 2011 - Elsevier
The coacervation of tropoelastin represents the first major stage of elastic fiber assembly.
The process has been modeled in vitro by numerous studies, initially with mixtures of …

Direct observation of structure and dynamics during phase separation of an elastomeric protein

…, LD Muiznieks, FW Keeley… - Proceedings of the …, 2017 - National Acad Sciences
Despite its growing importance in biology and in biomaterials development, liquid–liquid
phase separation of proteins remains poorly understood. In particular, the molecular …

Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin

…, RJ Stahl, EE Sitarz, CJ Lane, FW Keeley - Journal of Biological …, 2003 - ASBMB
Elastin is a polymeric structural protein that imparts the physical properties of extensibility and
elastic recoil to tissues. The mechanism of assembly of the tropoelastin monomer into the …