Fig 1. Schematic representation of the systemic inflammatory response (SIRS) to injury,
followed by a period of convalescence mediated by counter-regulatory anti-inflammatory …

The remarkable advances in molecular and cell biology occurring over the past four
decades have served the cause of surgical science well. Our understanding of basic disease …

The diversity of phenotypic manifestations, comorbidities, and therapeutic algorithms in patients
with severe inflammation have confounded efforts to translate mechanistic insights from …

Oligonucleotide and complementary DNA microarrays are being used to subclassify histologically
similar tumours, monitor disease progress, and individualize treatment regimens 1 , 2 , …

Bacterial infection of the mammalian bloodstream can lead to overwhelming sepsis, a potentially
fatal syndrome of irreversible cardiovascular collapse (shock) and critical organ failure. …

Tumor necrosis factor alpha (TNF alpha), a primary mediator of systemic responses to sepsis
and infection, can be injurious to the organism when present in excessive quantities. Here …

Cytokines secreted in response to invading micro-organisms are important mediators of
detrimental hemodynamic and metabolic changes in the host. To test whether cachectin/TNF …

We report the identification and purification of a new inflammatory monokine synthesized by
the macrophage tumor cell line RAW 264.7 in response to endotoxin. This monokine, which …

This work is part of a study of different types of plant-based biomass to elucidate their capacity
for valorisation via a managed carbonation step involving gaseous carbon dioxide (CO 2 )…

… F. Lowry. Proteolysis of skeletal muscle in response to acute elevation of plasma cortisol in
man. Surg. … Lowry, SF 1986. Host metabolic response to injury. In Advances in Host Defense …