Defects in death receptor-mediated apoptosis have been linked to cancer and autoimmune
disease in humans. The in vivo role of caspase 8, a component of this pathway, has eluded …

In Drosophila, the partition defective (Par) complex containing Par3, Par6 and atypical protein
kinase C (aPKC) directs the polarized distribution and unequal segregation of the cell fate …

A critical event in T cell receptor (TCR)-mediated signaling is the recruitment of
hematopoietic-specific adaptor proteins that collect and transmit signals downstream of the TCR …

Activation of the epidermal growth factor receptor (EGFR) results in internalization and
ubiquitin-dependent endosomal sorting, leading to lysosomal degradation. Here we describe the …

1,25-Dihydroxyvitamin D 3 (1,25-(OH) 2 D 3 ) primes NB4 cells for 12-O-tetradecanoylphorbol-13-acetate-induced
monocytic differentiation in a dose- and sequence-dependent fashion…

Gads is a member of the family of SH2 and SH3 domain containing adaptor proteins that is
expressed specifically in hematopoietic cells and functions in the coordination of tyrosine …

In the current research-focused climate, academics are facing increasing pressure to
produce research outputs. This pressure can prove particularly daunting for early career (EC) …

MIB1 belongs to the RING domain containing family of E3 ubiquitin ligases. In vertebrates,
MIB1 plays an essential role in activation of Notch signaling during development, through the …

Eye-tracking is increasingly studied as a cognitive and biological marker for the early signs
of neuropsychological and psychiatric disorders. However, in order to make further progress, …

The relationship between the binding affinity and specificity of modular interaction domains
is potentially important in determining biological signaling responses. In signaling from the T‐…