Background Antibiotics can disturb gastrointestinal microbiota which may lead to reduced
resistance to pathogens such as Clostridium difficile (C. difficile). Probiotics are live microbial …

Objective To evaluate risk factors for severe outcomes in patients with seasonal and pandemic
influenza. Design Systematic review. Study selection Observational studies reporting on …

Objective To investigate the credibility of authors’ claims of subgroup effects using a representative
sample of recently published randomised controlled trials. Design Systematic review. …

Background Lack of appropriate reporting of methodological details has previously been
shown to distort risk of bias assessments in randomized controlled trials. The same might be …

Importance The discontinuation of randomized clinical trials (RCTs) raises ethical concerns
and often wastes scarce research resources. The epidemiology of discontinued RCTs, …

Background Pregnancy is considered to be an important risk factor for severe complications
following influenza virus infection. As a consequence, WHO recommendations prioritize …

The anterior nares are the most important screening site of colonization with Staphylococcus
aureus. We screened 2966 individuals for S. aureus carriage with swabs of both nares and …

Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently
associated with poor prognosis, particularly in high-risk patients. The cornerstones in the …

The coronavirus disease 2019 (COVID-19) pandemic and antimicrobial resistance (AMR) are
parallel and interacting health emergencies that provide the opportunity for mutual learning…

Objectives To evaluate outcomes following implementation of a checklist with criteria for
switching from intravenous (iv) to oral antibiotics on unselected patients on two general medical …