Vitamin D is a steroid hormone precursor that is associated with a range of human traits and
diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four …

The end‐joining pathway of DNA double‐strand break (DSB) repair is necessary for proper
V(D)J recombination and repair of DSB caused by ionizing radiation. This DNA repair …

Cross‐sectional studies have repeatedly suggested peripheral blood monocyte telomere
length as a biomarker of aging. To test this suggestion in a large population‐based follow‐up …

Evidence is accumulating that aging is hormonally regulated by an evolutionarily conserved
insulin/IGF‐1 signalling (IIS) pathway. Mutations in IIS components affect lifespan in …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences 1 , 2 . Identification of expression …

Genetic risk factors often localize to noncoding regions of the genome with unknown effects
on disease etiology 1 , 2 . Expression quantitative trait loci (eQTLs) help to explain the …

Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. In the present study, we …

Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to
understand mechanisms underpinning gene regulation and disease. Here we describe …