Background: Heart failure is a leading cause of admission to hospital, but whether the incidence
of heart failure is increasing or decreasing is uncertain. We examined temporal trends in …

… Author links open overlay panel Darwin F. Yeung MD a , Sandra Sirrs MD b , Michael YC
Tsang MD a , Kenneth Gin MD a , Christina Luong MD a , John Jue MD a , Parvathy Nair MD a , …

The coiled-coil domain of the tripartite motif (TRIM) family protein TRIM5α is required for
trimerization and function as an antiretroviral restriction factor. Unlike the coiled-coil regions of …

Background Patients with heart failure with preserved ejection fraction (HFpEF) may have
elevated left ventricular filling pressure with exercise (LVFP-ex), despite normal LVFP at rest. …

Many tripartite motif (TRIM) proteins self-associate, forming dimers and higher order complexes.
For example, dimers of TRIM5α, a host factor that restricts retrovirus infection, assemble …

Fabry disease (FD) is an X-linked lysosomal storage disorder caused by mutations in the
galactosidase A (GLA) gene that result in deficient galactosidase A enzyme and subsequent …

… Author links open overlay panel River Jiang MD a , Darwin F. Yeung MD a , Delaram Behnami
MASc b , Christina Luong MD a , Michael YC Tsang MD a , John Jue MD a , Ken Gin MD …

Data from an upward-pointing wind profiler radar pair at Darwin in tropical Australia are used
to determine the characteristics of individual convective up- and downdrafts observed at …

Pulmonary artery sarcoma is a rare malignant neoplasm. Here, we describe a patient with a
pulmonary artery sarcoma, which was only subtly visible and therefore not fully appreciated …

In owl monkeys, the typical retroviral restriction factor of primates, TRIM5α, is replaced by
TRIMCyp. TRIMCyp consists of the TRIM5 RING, B-box 2 and coiled-coil domains, as well as …