Background Oncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK)
are present in a subgroup of non–small-cell lung cancers, representing 2 to 7% of such …

Purpose The EML4-ALK fusion oncogene represents a novel molecular target in a small
subset of non–small-cell lung cancers (NSCLC). To aid in identification and treatment of these …

Background Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene
receptor tyrosine kinase (ROS1) define a distinct molecular subgroup of non–small-cell lung …

Background ALK fusion genes occur in a subset of non-small-cell lung cancers (NSCLCs).
We assessed the tolerability and activity of crizotinib in patients with NSCLC who were …

Pelagic marine predators face unprecedented challenges and uncertain futures. Overexploitation
and climate variability impact the abundance and distribution of top predators in ocean …

Despite compelling antitumour activity of antibodies targeting the programmed death 1 (PD-1):
programmed death ligand 1 (PD-L1) immune checkpoint in lung cancer, resistance to …

Background ALK gene rearrangement defines a new molecular subtype of non-small-cell
lung cancer (NSCLC). In a recent phase 1 clinical trial, the ALK tyrosine-kinase inhibitor (TKI) …

BACKGROUND Sound is the sensory cue that travels farthest through the ocean and is used
by marine animals, ranging from invertebrates to great whales, to interpret and explore the …

Many epidemiologic reports associate ambient levels of particulate matter (PM) with human
mortality and morbidity, particularly in people with preexisting cardiopulmonary disease (eg, …

Although sources of airborne lead have been reduced over the last decade, particularly with
the use of lead-free gasoline, there are still relatively high levels of lead contamination in …