Lung cancer is the leading cause of cancer-related deaths in the world, and non-small-cell
lung cancer (NSCLC) accounts for 80% of cases. MicroRNA-21 (miR-21) expression is …

MicroRNAs inhibit mRNA translation or promote mRNA degradation by binding complementary
sequences in 3′ untranslated regions of target mRNAs. MicroRNA-21 (miR-21) is …

Objective: To describe prevalence and incidence of HIV-1, hepatitis C virus (HCV) and risk
behaviours in a prospective cohort of injecting drug users (IDU). Setting: Vancouver, which …

Background: Beginning in 1994, Vancouver experienced an explosive outbreak of HIV
infection among injection drug users (IDUs). The objectives of this study were to measure the …

Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling,
which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-…

Background In summer 2003, a respiratory outbreak was investigated in British Columbia,
during which nucleic acid tests and serology unexpectedly indicated reactivity for severe …

Background In late spring 2009, concern was raised in Canada that prior vaccination with the
2008–09 trivalent inactivated influenza vaccine (TIV) was associated with increased risk of …

Urban Norway and black rats (Rattus norvegicus and Rattus rattus) are the source of a number
of pathogens responsible for significant human morbidity and mortality in cities around …

BACKGROUND. Antibiotic exposure in early childhood is a possible contributor to the increasing
asthma prevalence in industrialized countries. Although a number of published studies …

Background The Canadian COVID-19 immunization strategy deferred second doses and
allowed mixed schedules. We compared two-dose vaccine effectiveness (VE) by vaccine type (…