It is uncertain whether environmental factors contribute to the formation of senile plaques and
neurofibrillary tangles, the abnormal features that define the Alzheimer's disease (AD) brain…

Our understanding of the activity of cationic antimicrobial peptides (AMPs) has focused on
well-characterized natural sequences, or limited sets of synthetic peptides designed de novo. …

BackgroundThe APOE genotype has a uniquely strong influence on the outcome of viral
infection. The mechanism is unknown, although one possibility is direct inhibition of viral entry …

Medical device infection remains a major clinical concern. Biocidal compounds have been
incorporated into medical device materials ideally to inhibit bacterial colonisation whilst …

Background The early events underlying Alzheimer's disease (AD) remain uncertain,
although environmental factors may be involved. Work in this laboratory has shown that the …

Diabetes has major implications for public health, with diabetic foot ulcers (DFUs) being
responsible for significant morbidity and mortality. A key factor in the development of nonhealing …

Microbicides (biocides) play an important role in the prevention and treatment of infections.
While there is currently little evidence for in-use treatment failures attributable to acquired …

Until recently, the only risk factors implicated in noninherited cases of Alzheimer’s disease
were increasing age, Down’s syndrome, and probably, head injury. Having found that herpes …

The causes that trigger the onset of dementia are still unknown. Recently there has been an
increasing interest in the possible role of infectious agents in the brain in the pathogenesis …

The number of people surviving to old age and concomitantly, the number affected by the
diseases of old age, is increasing steadily. Alzheimer's disease (AD) affects one in five people …