Insulin resistance plays an important role in the pathophysiology of diabetes and is associated
with obesity and other cardiovascular risk factors. The “gold standard” glucose clamp and …

Vitamin C in humans must be ingested for survival. Vitamin C is an electron donor, and this
property accounts for all its known functions. As an electron donor, vitamin C is a potent water…

Background: Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical
studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-…

The objectives of this study were to evaluate test characteristics, such as normality of distribution,
variation, and repeatability, of simple fasting measures of insulin sensitivity and to use …

Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes,
may improve symptoms and prolong life in patients with terminal cancer. Double-blind …

Background—The mechanism of the hemodynamic effect of insulin in the skeletal muscle
circulation has not been fully elucidated. The purpose of this study was to assess whether the …

Liver X‐receptor (LXR) agonists have been postulated to enhance reverse cholesterol
transport (RCT), a process believed to shuttle cholesterol from the periphery back to the liver. …

Endothelial dysfunction is a hallmark of Type 2 diabetes related to hyperglycemia and
oxidative stress. Nitric oxide-dependent vasodilator actions of insulin may augment glucose …

Insulin resistance may link disorders of metabolic homeostasis such as diabetes and obesity
with disorders of hemodynamic homeostasis such as hypertension. Thus it is of interest to …

Background: Glycated hemoglobin (HbA1c) and measures of short-term glycemia do not
fully capture daily patterns in plasma glucose dynamics. This study evaluated 24-h glycemic …