Aims The first aim was to critically evaluate the extent to which familial hypercholesterolaemia
(FH) is underdiagnosed and undertreated. The second aim was to provide guidance for …

Aims The aims of the study were, first, to critically evaluate lipoprotein(a) [Lp(a)] as a
cardiovascular risk factor and, second, to advise on screening for elevated plasma Lp(a), on …

ContextElevated nonfasting triglycerides indicate the presence of remnant lipoproteins,
which may promote atherosclerosis.ObjectiveTo test the hypothesis that very high levels of …

Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. To elucidate
the molecular basis of NAFLD, we performed an exome-wide association study of liver …

Background High plasma levels of nonfasting triglycerides are associated with an increased
risk of ischemic cardiovascular disease. Whether lifelong low levels of nonfasting …

Background Elevated levels of C-reactive protein (CRP) are associated with increased risks
of ischemic heart disease and ischemic cerebrovascular disease. We tested whether this is …

Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition
characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (…

Familial hypercholesterolaemia (FH) is a common genetic cause of premature coronary heart
disease (CHD). Globally, one baby is born with FH every minute. If diagnosed and treated …

Background Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been
associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …

Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a lower …