Biological agents for rheumatoid arthritis: targeting both physical function and structural damage

A Klinkhoff - Drugs, 2004 - Springer
Rheumatoid arthritis (RA) is a chronic progressive inflammatory disease of multifactorial
aetiology. The pivotal role of proinflammatory cytokines in the pathogenesis and perpetuation of …

A 48‐week, randomized, double‐blind, double‐observer, placebo‐controlled multicenter trial of combination methotrexate and intramuscular gold therapy in …

AJ Lehman, JM Esdaile, AV Klinkhoff… - Arthritis & …, 2005 - Wiley Online Library
Objective To evaluate the efficacy and safety of adding intramuscular (IM) gold to the treatment
regimen of patients with rheumatoid arthritis (RA) who have a suboptimal response to …

The clinical assessment of patients with psoriatic arthritis: results of a reliability study of the spondyloarthritis research consortium of Canada.

…, RI Inman, C Hitchon, J Karsh, AV Klinkhoff… - The Journal of …, 2004 - jrheum.org
OBJECTIVES: To evaluate whether rheumatologists experienced in psoriatic arthritis (PsA)
assess peripheral and axial involvement in the same way and to consider core clinical …

Retinopathy in systemic lupus erythematosus: relationship to disease activity

AV Klinkhoff, CW Beattie… - Arthritis & Rheumatism …, 1986 - Wiley Online Library
Forty‐three patients taking chloroquine for systemic lupus erythematosus were followed by
one ophthalmologist over a 5‐year period. Visual field testing, color vision testing, and …

M-mode and two-dimensional echocardiographic abnormalities in systemic lupus erythematosus

AV Klinkhoff, CR Thompson, GD Reid, CW Tomlinson - JAMA, 1985 - jamanetwork.com
A prospective clinical and echocardiographic study of 47 patients with systemic lupus
erythematosus (SLE) and 46 age- and sex-matched controls showed an increased prevalence of …

Rheumatology: 5. Diagnosis and management of inflammatory polyarthritis

A Klinkhoff - Cmaj, 2000 - Can Med Assoc
The case: Three months after an uncomplicated pregnancy and delivery Mrs. D consults her
physician about new pain and swelling in her wrists and several proximal interphalangeal …

The Canadian Rheumatology Association/Spondyloarthritis Research Consortium of Canada treatment recommendations for the management of spondyloarthritis: a …

…, S Dimond, P Fortin, J Karsh, AV Klinkhoff… - The Journal of …, 2007 - jrheum.org
OBJECTIVE: Development of treatment recommendations for arthritis has traditionally relied
on the compilation of evidence-based data by experts in the field despite recommendations …

Probabilistic threshold technique showed that patients' preferences for specific trade-offs between pain relief and each side effect of treatment in osteoarthritis varied

…, H Llewellyn-Thomas, A Klinkhoff… - Journal of clinical …, 2007 - Elsevier
OBJECTIVES: Therapeutic decisions in osteoarthritis (OA) often involve trade-offs between
accepting risks of side effects and gaining pain relief. Our objectives were (1) to determine …

Longterm therapy of psoriatic arthritis: intramuscular gold or methotrexate?

…, HB Stein, J Raboud, AV Klinkhoff - The Journal of …, 2000 - europepmc.org
Objective To compare the efficacy and toxicity of methotrexate (MTX) and intramuscular (im)
gold in the treatment of psoriatic arthritis (PsA). Methods Medical records from all patients …

Laser induced chrysiasis: disfiguring hyperpigmentation following Q-switched laser therapy in a woman previously treated with gold.

H Almoallim, AV Klinkhoff, AB Arthur, JK Rivers… - The Journal of …, 2006 - jrheum.org
We describe a 40-year-old woman with rheumatoid arthritis and a history of 2 previous courses
of intramuscular gold who developed disfiguring hyperpigmentation immediately after Q-…