Study Objective: To determine whether obesity preceded knee osteoarthritis and was thus a
possible cause. Design: Cohort study with weight and other important variables measured in …

Objective. To quantify the incidence of symptomatic hand, hip, and knee osteoarthritis (OA)
among members of the Fallon Community Health Plan, a health maintenance organization …

Background Multivitamin supplementation in pregnant women may reduce the risks of
cardiovascular defects, oral clefts, and urinary tract defects in their infants. We evaluated whether …

Observational studies often provide the only available information about treatment effects.
Control of confounding, however, remains challenging. The authors compared five methods …

Studies have shown a positive association between obesity and knee osteoarthritis. Studies
evaluating hand or hip osteoarthritis and weight, however, have assessed x-ray …

Background Reports of multiple sclerosis developing after hepatitis B vaccination have led
to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy …

• We carried out a study to estimate the incidence of erythema multiforme (EM), Stevens
Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) requiring hospitalization and to …

Background Discontinuation rates for drugs used to treat chronic conditions may affect the
success of therapy. However, the discontinuation rates reported in clinical trials may not reflect …

PURPOSE: The present study describes the patterns and predictors of treatment persistence
and adherence among patients who are diagnosed with glaucoma or as glaucoma …

Clozapine (Clozaril), a tricyclic dibenzodiazepine, causes fewer extrapyramidal side effects
than do other antipsychotic drugs. Because it can induce agranulocytosis, however, …