[HTML][HTML] Rational use of tocilizumab in the treatment of novel coronavirus pneumonia

S Zhang, L Li, A Shen, Y Chen, Z Qi - Clinical drug investigation, 2020 - Springer
Since December 2019, a novel coronavirus pneumonia (COVID-19) has broken out in Wuhan,
China and spread rapidly. Recent studies have found that ⁓ 15.7% of patients develop …

Advances in anti-breast cancer drugs and the application of nano-drug delivery systems in breast cancer therapy

X Fang, J Cao, A Shen - Journal of Drug Delivery Science and Technology, 2020 - Elsevier
Breast cancer is one of the most common malignant tumors among women. Although the
traditional breast cancer therapies are effective, there have numerous shortcomings, including …

Advances and challenges in deep generative models for de novo molecule generation

…, Z Yang, G Chuai, S Qu, A Shen… - Wiley …, 2019 - Wiley Online Library
The de novo molecule generation problem involves generating novel or modified molecular
structures with desirable properties. Taking advantage of the great representation learning …

Oxygen self‐supply engineering‐ferritin for the relief of hypoxia in tumors and the enhancement of photodynamic therapy efficacy

…, D Jin, M Liu, Y Dai, L Li, X Zheng, L Wang, A Shen… - Small, 2022 - Wiley Online Library
Hypoxia is a hallmark of the tumor microenvironment (TME) that promotes tumor development
and metastasis. Photodynamic therapy (PDT) is a promising strategy in the treatment of …

Nitric‐Oxide‐Releasing aza‐BODIPY: A New Near‐Infrared J‐Aggregate with Multiple Antibacterial Modalities

X Bao, S Zheng, L Zhang, A Shen, G Zhang… - Angewandte …, 2022 - Wiley Online Library
The development of near‐infrared (NIR) J‐aggregates has received increasing attention
due to their broad applications. Here, we report the nitrosation of an amine‐containing aza‐…

[HTML][HTML] Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study

…, Z Kuang, Y Luo, T Yang, J Xu, J Yu, C Wen, A Shen - Scientific Reports, 2021 - nature.com
Treating patients with COVID-19 is expensive, thus it is essential to identify factors on admission
associated with hospital length of stay (LOS) and provide a risk assessment for clinical …

[HTML][HTML] The lncRNA-GAS5/miR-221-3p/DKK2 axis modulates ABCB1-mediated adriamycin resistance of breast cancer via the Wnt/β-catenin signaling pathway

…, T Pan, D Jiang, L Jin, Y Geng, X Feng, A Shen… - … Therapy-Nucleic Acids, 2020 - cell.com
Drug resistance, including adriamycin (ADR)-based therapeutic resistance, is a crucial cause
of chemotherapy failure in breast cancer treatment. Acquired chemoresistance has been …

[HTML][HTML] Novel coronavirus (SARS-CoV-2) infection in a renal transplant recipient: case report

…, Z Yao, S Zhang, D Zhao, B Nashan, A Shen… - American journal of …, 2020 - Elsevier
An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus
2 (SARS-CoV-2) started in Wuhan, China, with cases now confirmed in multiple countries. …

The short-term effects of air pollutants on hospitalizations for respiratory disease in Hefei, China

J Xie, J Teng, Y Fan, R Xie, A Shen - International journal of …, 2019 - Springer
Previous studies have shown that ambient air pollution is associated with respiratory morbidity.
However, the effects of air pollutants on health have rarely been studied in China. Our …

[HTML][HTML] Treatment of patients with nonsevere and severe coronavirus disease 2019: an evidence-based guideline

…, RA Fowler, H Qiu, L Wei, L Sang, M Loeb, N Shen… - Cmaj, 2020 - Can Med Assoc
2019 (COVID-19) is either indirect (from studies of influenza, severe acute respiratory
syndrome and Middle East respiratory syndrome) or from several observational studies and …