Des chercheurs ont demontre qu'une hor-mone, l'interleukine-4, peut redonner aux cellules
T leur capacite protectrice et prevenir ainsile diabete chez des souris diabetiques non …

Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in …

It is unknown whether interleukin-1 exerts a bimodal effect on Beta-cell function in vivo, and
whether interleukin-1 has a diabetogenic action in normal animals. We therefore studied:(a) …

Interleukin 1 (IL-1), a cytokine released mainly by activated macrophages-monocytes, affects
glucose homeostasis and may mediate some of the metabolic derangements observed …

The nonobese diabetic (NOD) mouse spontaneously develops a diabetic syndrome that
closely resembles human insulin-dependent diabetes mellitus (IDDM). T cell-mediated …

Abstract Interleukin-6 (IL-6) is a multifunctional cytokine regulating humoral and cellular
responses and playing a central role in inflammation and tissue injury. Its effects are …

Background An improper balance of regulatory/effector T (T reg/T eff) cells is central to the
development of autoimmune diseases, including type 1 diabetes. We previously showed …

With the discovery of a number of immunomodulatory cytokines 15 to 20 years ago [1, 2]
came the observation that so-called “inflammatory cytokines” such as TNFα, IL-6, IL-1α and …

We evaluated the effects of recombinant human (rh) interleukin (IL)-11 on the development
of spontaneous and cyclophosphamide-induced diabetes in female NOD mice. Prolonged …

Cells involved in immune responses, inflammation, and development are sensitive to
interleukin-1 (IL-1). In recent years, many studies have addressed the effects of IL-1 on …