Abstract
We describe a case of severe morphine-induced itch unrelieved by antihistamines, which responded to a change to hydromorphone. The possible mechanisms of opioid-induced itch are briefly discussed. It is unclear if it is due to histamine release, an opioid-receptor mediated effect, or idiosyncratic drug reaction.
MeSH terms
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Analgesics, Opioid / adverse effects*
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Analgesics, Opioid / therapeutic use
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Humans
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Hydromorphone / adverse effects*
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Hydromorphone / therapeutic use
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Male
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Middle Aged
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Morphine / adverse effects*
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Morphine / therapeutic use
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Pain, Intractable / complications
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Pain, Intractable / drug therapy
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Palliative Care
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Pruritus / chemically induced*
Substances
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Analgesics, Opioid
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Morphine
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Hydromorphone