Idiopathic CD4+ T-lymphocytopenia in a child with disseminated cryptococcosis

Ann Trop Paediatr. 1998 Mar;18(1):45-8. doi: 10.1080/02724936.1998.11747925.

Abstract

We describe a Malay girl with disseminated cryptococcosis affecting the lungs, liver, lymph nodes and bones. The diagnosis was made by culture of the bone marrow. Tests of immune function showed that she was HIV-negative but the CD4 percentage was persistently low. Idiopathic CD4+ T-lymphocytopenia was diagnosed. The child died despite two courses of anti-fungal therapy.

Publication types

  • Case Reports

MeSH terms

  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Antigens, Fungal / blood
  • Bone Marrow / microbiology
  • Child, Preschool
  • Cryptococcosis / complications*
  • Cryptococcosis / drug therapy
  • Cryptococcosis / immunology
  • Drug Therapy, Combination
  • Fatal Outcome
  • Female
  • Fluconazole / therapeutic use
  • Flucytosine / therapeutic use
  • Humans
  • Liver / microbiology
  • Lung / microbiology
  • Lymph Nodes / microbiology
  • T-Lymphocytopenia, Idiopathic CD4-Positive / complications*
  • T-Lymphocytopenia, Idiopathic CD4-Positive / immunology

Substances

  • Antifungal Agents
  • Antigens, Fungal
  • Amphotericin B
  • Fluconazole
  • Flucytosine