Abstract
We describe a bullous-hemorrhagic reaction of the ear lobes in a child with nephrosis after levamisole intake. This drug is used in children as an alternative treatment of corticosteroid-responsive nephrotic syndrome. Histologic evaluation of a lesion revealed necrotizing vasculitis involving mainly the large vessels of the deep plexus. The lesions disappeared 25 days after discontinuation of treatment.
MeSH terms
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Adjuvants, Immunologic / adverse effects*
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Adjuvants, Immunologic / therapeutic use
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Arterial Occlusive Diseases / chemically induced*
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Biopsy
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Child
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Ear, External / blood supply
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Ear, External / pathology*
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Humans
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Levamisole / adverse effects*
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Levamisole / therapeutic use
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Necrosis
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Nephrotic Syndrome / drug therapy
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Skin / blood supply
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Skin Diseases, Vesiculobullous / chemically induced*
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Skin Diseases, Vesiculobullous / pathology
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Vasculitis / chemically induced*
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Vasculitis / pathology
Substances
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Adjuvants, Immunologic
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Levamisole