Abstract
We performed a randomized, double-blind, placebo-controlled study to determine whether acute otitis media could be prevented by antibiotic therapy initiated promptly after the appearance of symptoms of upper respiratory tract infection. One hundred four children aged 1 to 4 years received a 7-day course of either amoxicillin-clavulanate or placebo. Acute otitis media developed in 9 (18%) of the 50 children receiving amoxicillin clavulanate and in 12 (22%) of the 54 children receiving placebo (p = 0.59).
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acute Disease
-
Amoxicillin / therapeutic use
-
Amoxicillin-Potassium Clavulanate Combination
-
Chi-Square Distribution
-
Child, Preschool
-
Clavulanic Acids / therapeutic use
-
Double-Blind Method
-
Drug Therapy, Combination / therapeutic use*
-
Female
-
Humans
-
Male
-
Otitis Media / diagnosis
-
Otitis Media / prevention & control*
-
Respiratory Tract Infections / diagnosis
-
Respiratory Tract Infections / drug therapy*
-
Respiratory Tract Infections / virology
-
Statistics, Nonparametric
-
Time Factors
Substances
-
Clavulanic Acids
-
Amoxicillin-Potassium Clavulanate Combination
-
Amoxicillin