Resistance to activate protein C, the Arg506 to Gln mutation in the factor V gene, and venous thrombosis. Functional tests and DNA-based assays, pros and cons

MeSH terms

• Base Sequence
• Enzyme Activation
• Factor V / analysis
• Factor V / genetics*
• Factor V Deficiency / complications*
• Factor V Deficiency / diagnosis
• Factor V Deficiency / genetics
• Genetic Predisposition to Disease
• Humans
• Molecular Sequence Data
• Partial Thromboplastin Time*
• Point Mutation*
• Polymerase Chain Reaction*
• Prevalence
• Protein C / analysis
• Protein C / metabolism*
• Pulmonary Embolism / etiology
• Risk Factors
• Sensitivity and Specificity
• Thrombophlebitis / epidemiology
• Thrombophlebitis / etiology*