Abstract
Trimethoprim-sulfamethoxazole is known to produce hepatitis. We report a case involving the inadvertent rechallenge with trimethoprim-sulfamethoxazole (Bactrim) in a patient with a previous episode of drug-induced hepatitis. A liver biopsy specimen showed both cholestatic and cytotoxic changes consistent with drug-induced damage. Comparison with existing cases is presented and an immunologic cause is considered.
MeSH terms
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Biopsy
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Chemical and Drug Induced Liver Injury / etiology*
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Chemical and Drug Induced Liver Injury / pathology
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Cholestasis, Intrahepatic / chemically induced*
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Cholestasis, Intrahepatic / pathology
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Drug Combinations / adverse effects
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Humans
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Liver / pathology
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Male
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Middle Aged
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Sulfamethoxazole / adverse effects*
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Trimethoprim / adverse effects*
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Trimethoprim, Sulfamethoxazole Drug Combination
Substances
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Drug Combinations
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Trimethoprim, Sulfamethoxazole Drug Combination
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Trimethoprim
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Sulfamethoxazole