Abstract
This study compared the hypnotic efficacy and the psychometric effects of treatment with either chlormethiazole or triazolam for 9 weeks in elderly patients with sleep disturbance. Chlormethiazole and triazolam were found to be similarly effective in short-term use. However, evidence of sustained hypnotic efficacy throughout the 9 weeks of treatment was obtained for chlormethiazole but not for triazolam. There were daytime withdrawal effects with triazolam, but none with chlormethiazole.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Aged
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Arousal / drug effects
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Chlormethiazole / adverse effects
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Chlormethiazole / therapeutic use*
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Clinical Trials as Topic
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Double-Blind Method
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Female
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Flicker Fusion / drug effects
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Humans
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Male
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Random Allocation
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Reaction Time / drug effects
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Sensory Thresholds
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Sleep Initiation and Maintenance Disorders / drug therapy*
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Sleep Stages / drug effects
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Triazolam / adverse effects
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Triazolam / therapeutic use*
Substances
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Chlormethiazole
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Triazolam