New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada

Michael R Mulvey; Jennifer M Grant; Katherine Plewes; Diane Roscoe; David A Boyd

doi:10.3201/eid1701.101358

New Delhi metallo-β-lactamase in Klebsiella pneumoniae and Escherichia coli, Canada

Emerg Infect Dis. 2011 Jan;17(1):103-6. doi: 10.3201/eid1701.101358.

Authors

Michael R Mulvey¹, Jennifer M Grant, Katherine Plewes, Diane Roscoe, David A Boyd

Affiliation

¹ Antimicrobial Resistance and Nosocomial Infections section, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. michael.mulvey@phac-aspc.gc.ca

Abstract

Multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates harboring New Delhi metallo-β-lactamase (NDM-1) were isolated from a patient who had returned to Canada from India. The NDM-1 gene was found on closely related incompatibility group A/C type plasmids. The occurrence of NDM-1 in North America is a major public health concern.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents / pharmacology
Canada / epidemiology
Drug Resistance, Multiple, Bacterial*
Escherichia coli / drug effects*
Escherichia coli / enzymology
Escherichia coli / genetics
Escherichia coli / isolation & purification
Escherichia coli Infections / epidemiology*
Escherichia coli Infections / microbiology
Fatal Outcome
Female
Humans
India
Klebsiella Infections / epidemiology*
Klebsiella Infections / microbiology
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / enzymology
Klebsiella pneumoniae / genetics
Klebsiella pneumoniae / isolation & purification
Microbial Sensitivity Tests
Plasmids
Travel
beta-Lactamases* / genetics
beta-Lactamases* / metabolism

Substances

Anti-Bacterial Agents
beta-Lactamases
beta-lactamase NDM-1