Preeclampsia and risk of developing subsequent diabetes

Hypertens Pregnancy. 2009 Aug;28(4):435-47. doi: 10.3109/10641950802629675.

Abstract

Objective: Determine whether preeclampsia is associated with developing diabetes.

Methods: Subsequent diabetes was ascertained using ICD-9 codes, pharmacy and glucose data in a retrospective cohort study of 2,032 women with preeclampsia and 29,431 without preeclampsia.

Results: During a median follow-up of 8.2 years, 342 women developed diabetes. Preeclampsia was associated with a higher risk of diabetes adjusting for age, primigravidity, and gestational diabetes (hazard ratio, HR 1.82, 95%CI 1.26, 2.62) and in women without gestational diabetes (n = 30,109; HR 1.86, 95%CI 1.22, 2.84).

Conclusion: Women with preeclampsia have greater risk of developing diabetes, even in the absence of gestational diabetes.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Age Factors
  • Blood Glucose / metabolism
  • Cohort Studies
  • Diabetes Mellitus, Type 2 / etiology*
  • Diabetes Mellitus, Type 2 / metabolism
  • Diabetes, Gestational / metabolism*
  • Female
  • Humans
  • International Classification of Diseases
  • Pre-Eclampsia / metabolism*
  • Pregnancy
  • Retrospective Studies
  • Risk

Substances

  • Blood Glucose