Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin

Richard H Steele; Sandhya Limaye; Bruce Cleland; Josephine Chow; Michael G Suranyi

doi:10.1111/j.1440-1797.2005.00389.x

Hypersensitivity reactions to the polysorbate contained in recombinant erythropoietin and darbepoietin

Nephrology (Carlton). 2005 Jun;10(3):317-20. doi: 10.1111/j.1440-1797.2005.00389.x.

Authors

Richard H Steele¹, Sandhya Limaye, Bruce Cleland, Josephine Chow, Michael G Suranyi

Affiliation

¹ Department of Immunology, Liverpool Hospital, Liverpool BC, New South Wales, Australia. richard.steele@ccdhb.org.nz

PMID: 15958049
DOI: 10.1111/j.1440-1797.2005.00389.x

Abstract

The following case reports are of two patients who have developed hypersensitivity reactions to the red cell growth hormones, darbepoietin and erythropoietin. The subsequent skin testing and clinical course suggested that the cause of these reactions was due to the excipient polysorbate 80. This finding might have implications in the recent increase in the incidence of pure red cell aplasia.

Publication types

Case Reports

MeSH terms

Adult
Aged
Anemia / drug therapy*
Anemia / etiology
Darbepoetin alfa
Drug Hypersensitivity / etiology*
Erythropoietin / administration & dosage*
Erythropoietin / adverse effects
Erythropoietin / analogs & derivatives*
Excipients / adverse effects*
Female
Humans
Kidney Failure, Chronic / complications
Polysorbates / adverse effects*
Recombinant Proteins

Substances

Excipients
Polysorbates
Recombinant Proteins
Erythropoietin
Darbepoetin alfa