General Obstetrics and Gynecology GynecologyPersistent low levels of human chorionic gonadotropin: A premalignant gestational trophoblastic disease☆
Section snippets
Methods
The USA hCG Reference Service is a College of American Pathologist monitored (No. 7176750-01) and Department of Health and Human Services CLIA certified (No. 32D0972561) reference facility. The service considers brief patient histories and the results of multiple tests on supplied parallel serum and urine samples. Samples are initially tested by using the automated DPC Immulite hCG test, the DPC Immulite free hCGβ test, Abbott AxSym total hCG test, and other commercial hCG tests as needed.
Serum
Results
Table I outlines the clinical histories provided for the 63 patients with persistent low-level hCG determinations.
Comment
In this study, the clinical presentation and follow-up of 63 women with low hCG titers that persisted for 6 months to 6 years are discussed. In all cases, the diagnosis of persistent gestational trophoblastic disease was rendered, although no tumor could be identified by CT or magnetic resonance imaging. Most cases (64%) received single or multiagent chemotherapy, surgery, or a combination. Despite therapy, measurable circulating hCG persisted. In all 38 cases evaluated by the ITA assay, no or
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Cited by (56)
False Positive HCG Assays
2010, Human Chorionic Gonadotropin (hCG)Use of Hyperglycosylated hCG as a Unique Marker of Gestational Trophoblastic Neoplasms
2010, Human Chorionic Gonadotropin (hCG)USA hCG reference service, 10-year report
2010, Clinical Biochemistry
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Reprint request to: Laurence A. Cole, PhD, Department Obstetrics and Gynecology, Division of Women's Health Research, USA hCG Reference Service, University of New Mexico, 2211 Lomas Blvd, NE, Albuquerque, NM 87131. E-mail: [email protected]