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Health economics of asthma and rhinitis. II. Assessing the value of interventions,☆☆,

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Abstract

Health care providers and payers are being asked to weigh data on the economic impact of new interventions along with clinical evidence when making decisions about the care of patients. The notion of incorporating formal health economic assessments into clinical and resource decisions is a difficult concept for many in the health care sector. However, it is the reality in today’s environment. To effectively participate in these ongoing discussions, clinicians and other decision makers must be able to understand and critically assess the evidence on economic impact of medical interventions. This second of 2 articles describes the elements of comparative economic evaluations, reviewing the published literature on asthma and rhinitis in an attempt to critically appraise the studies from the perspective of one who might use data for decision making. Unfortunately, the quality of the economic evidence in these two disease states is not extensive. Until better economic analyses are conducted and made available, the allocation of resources for asthma and allergic rhinitis will continue to primarily rely on expert opinion rather than evidence-based literature. (J Allergy Clin Immunol 2001;107:203-10.)

Section snippets

Basic principles of CEA

CEA can be defined as a set of related methods to assess and quantify the costs and clinical consequences of medical care treatments to estimate the “economic value” of the intervention in relation to alternative treatments. These methods were described briefly in the first part of this review.3 A CEA of competing medical treatments should incorporate evidence on the clinical consequences (efficacy and safety) and the costs and relative cost-effectiveness of treatment alternatives.7, 8

Assessment of value in the care of persons with asthma and rhinitis

Following is a concise review of studies of both asthma and allergic rhinitis that highlight the utility of economic evaluations for clinical and resource decision making. Only a few of these studies have met recommended standards for economic evaluation.9, 10, 11 The review emphasizes studies that conform to appropriate scientific rigor but also points out notable studies that fail to meet guidelines. Also identified are important or contemporary interventions that lack even basic published

Conclusion

The health economic literature for asthma and rhinitis has evolved considerably during the past decade. CEA is now recognized as a standardized methodology for assisting decision makers in selecting and reimbursing health care interventions that maximize the health of populations, given the conflicts generated by constrained health budgets and the rising demand for medical care. Unfortunately, much of the literature in asthma and rhinitis, while evolving, does not currently meet accepted

Acknowledgements

We thank Ms Robin Wagner for her editorial assistance and Ms Josephine Diaz and Ms Monica Blumthal for their assistance with document retrieval.

References (100)

  • R Kauppinen et al.

    One-year economic evaluation of intensive vs conventional patient education and supervision for self-management of new asthmatic patients

    Respir Med

    (1998)
  • CS Ghosh et al.

    Reductions in hospital use from self management training for chronic asthmatics

    Soc Sci Med

    (1998)
  • DL Zwicke et al.

    Use of the emergency department observation unit in the treatment of acute asthma

    Ann Am Med

    (1982)
  • T Doan et al.

    An intervention program to reduce the hospitalization cost of asthma patients requiring intubation

    Ann Allergy Asthma Immunol

    (1996)
  • R Bailey et al.

    Impact of clinical pathways and practice guidelines on the management of acute exacerbations of bronchial asthma

    Chest

    (1998)
  • DK Greineder et al.

    A randomized controlled trial of a pediatric asthma outreach program

    J Allergy Clin Immunol

    (1999)
  • JF O’Connor et al.

    The cost-effectiveness of strategies to assess gastroesophageal reflux as an exacerbating factor in asthma

    Am J Gastroenterol

    (1999)
  • HC Deter

    Cost-benefit analysis of psychosomatic therapy in asthma

    J Psychosom Res

    (1986)
  • WP Munroe et al.

    Economic evaluation of pharmacist involvement in disease management in a community pharmacy setting

    Clin Ther

    (1997)
  • CM Kozma et al.

    A comparison of costs and efficacy of intranasal fluticasone propionate and terfenadine tablets for seasonal allergic rhinitis

    Clin Ther

    (1996)
  • E Stahl et al.

    Cost-effectiveness analysis of budesonide aqueous nasal spray and fluticasone propionate nasal spray in the treatment of perennial allergic rhinitis

    Ann Allergy Asthma Immunol

    (2000)
  • PK Keith et al.

    A cost-benefit analysis using a willingness-to-pay questionnaire of intranasal bude-sonide for seasonal allergic rhinitis

    Ann Allergy Asthma Immunol

    (2000)
  • Counsel on Ethical and Judicial Affairs, American Medical Association

    Ethical issues in managed care

    JAMA

    (1995)
  • KB Weiss et al.

    The health economics of asthma and rhinitis. I. Assessing the economic impact

    J Allergy Clin Immunol

    (2000)
  • MF Drummond et al.

    Methods for the economic evaluation of health care programmes

    (1997)
  • MF Drummond et al.

    Methods for the economic evaluation of health care programmes

    (1987)
  • HD Banta et al.

    Health care technology and its assessment

    (1993)
  • KE Warner et al.

    Cost-benefit and cost-effectiveness analysis in health care: principles, practice, and potential

    (1982)
  • AM Garber et al.

    Theoretical foundations of cost-effectiveness analysis

  • S Sullivan et al.

    National Asthma Education and Prevention Program working group report on the cost-effectiveness of asthma care

    Am J Respir Crit Care Med

    (1996)
  • National Asthma Education and Prevention Program. Expert panel report: guidelines for the diagnosis and management of asthma

    (April 1997)
  • G van den Boom et al.

    Active detection of chronic obstructive pulmonary disease and asthma in the general population

    Am J Respir Crit Care Med

    (1998)
  • S Suissa et al.

    Effectiveness of leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma: a randomized, double-blind, placebo-controlled trial

    Ann Intern Med

    (1997)
  • J Lord et al.

    Cost effectiveness analysis of inhaled anticholinergics for acute childhood and adolescent asthma

    BMJ

    (1999)
  • PC Booth et al.

    A comparison of the cost effectiveness of alternative prophylactic therapies in childhood asthma

    Pharmacoeconomics

    (1996)
  • LM Campbell et al.

    A comparison of the cost-effectiveness of budesonide 400 μg/day and 800 μg/day in the management of mild-to-moderate asthma in general practice

    Br J Med Econ

    (1993)
  • MJ Sculpher et al.

    Episode-free days as endpoints in economic evaluations of asthma therapy

    Pharmacoeconomics

    (1993)
  • G Johansson et al.

    Cost-effectiveness analysis of salmeterol/fluticasone propionate 50/100 microgram versus fluticasone propionate 100 microgram in adults and adolescents with asthma. III: Results

    Pharmacoeconomics

    (1999)
  • M Palmqvist et al.

    Cost-effectiveness analysis of salmeterol/fluticasone propionate 50/250 microgram versus fluticasone propionate 250 micrograms versus fluticasone propionate 250 micrograms in adults and adolescents with asthma. IV: Results

    Pharmacoeconomics

    (1999)
  • WR Pieters et al.

    Cost-effectiveness analysis of salmeterol/fluticasone 50/500 micrograms versus fluticasone propionate 500 micrograms in patients with corticosteroid-dependent asthma. V: Results

    Pharmacoeconomics

    (1999)
  • PJ Barnes et al.

    Efficacy and safety of inhaled corticosteroids in asthma

    Am Rev Respir Dis

    (1993)
  • The Childhood Asthma Management Program Research Group

    Long-term effects of budesonide or nedocromil in children with asthma

    N Engl J Med

    (2000)
  • UG Gerdtham et al.

    Impact of inhaled corticosteroids on acute asthma hospitalization in Sweden 1978-1991

    Med Care

    (1996)
  • BJ Perera

    Efficacy and cost effectiveness of inhaled steroids in asthma in a developing country

    Arch Dis Child

    (1995)
  • SS Holzer et al.

    Asthma treatment costs using inhaled corticosteroids

    Am J Managed Care

    (1997)
  • S Barton

    Which clinical studies provide the best evidence? The best RCT still trumps the best observational study

    BMJ

    (2000)
  • SJ Popcock et al.

    Randomized trials of observational tribulations?

    N Engl J Med

    (2000)
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    Supported by a grant from Astra Pharmaceuticals, Westborough, Mass

    ☆☆

    Supported in part by an educational grant from the Asthma and Allergy Foundation of America.

    Reprint requests: Kevin B. Weiss, MD, Director, Center for Health Services Research, Rush Primary Care Institute, Rush-Presbyterian-St Luke’s Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612.

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