American Gastroenterological Association (AGA) InstituteAGA Institute Medical Position Statement on Acute Pancreatitis
Section snippets
Diagnosis
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The diagnosis of acute pancreatitis should be established within 48 hours of admission. The diagnosis should be based on compatible clinical features and elevations in amylase or lipase levels. Elevations in amylase or lipase levels greater than 3 times the upper limit of normal, in the absence of renal failure, are most consistent with acute pancreatitis. Elevations in amylase or lipase levels less than 3 times the upper limit of normal have low specificity for acute pancreatitis and hence are
Reference (1)
- et al.
AGA Institute Technical Review on acute pancreatitis
Gastroenterology
(2007)
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2019, PancreatologyCitation Excerpt :We must note that either direct pathologic insult of the pancreas i.e., alcohol, bile or fatty acids [14], or increased autoactivation of trypsinogen [15] without infection can activate inflammatory pathways, therefore AP itself is not an indication for AB therapy [16,17]. Notably, current guidelines do not recommend prophylactic AB therapy for the prevention of infectious complications in AP (IAP/APA guideline, Grade 1B) [18], (American College of Gastroenterology, strong recommendation, moderate quality of evidence) [19]. However, in cases of proven source of infection empiric administration of ABs is justified [20].