Gastroenterology

Gastroenterology

Volume 132, Issue 5, May 2007, Pages 2019-2021
Gastroenterology

American Gastroenterological Association (AGA) Institute
AGA Institute Medical Position Statement on Acute Pancreatitis

https://doi.org/10.1053/j.gastro.2007.03.066Get rights and content

This document presents the official recommendations of the American Gastroenterological Association (AGA) Institute on “Management of Acute Pancreatitis.” It was approved by the Clinical Practice and Economics Committee on February 14, 2007, and by the AGA Institute Governing Board on March 15, 2007.

Section snippets

Diagnosis

  • The diagnosis of acute pancreatitis should be established within 48 hours of admission. The diagnosis should be based on compatible clinical features and elevations in amylase or lipase levels. Elevations in amylase or lipase levels greater than 3 times the upper limit of normal, in the absence of renal failure, are most consistent with acute pancreatitis. Elevations in amylase or lipase levels less than 3 times the upper limit of normal have low specificity for acute pancreatitis and hence are

Reference (1)

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    We must note that either direct pathologic insult of the pancreas i.e., alcohol, bile or fatty acids [14], or increased autoactivation of trypsinogen [15] without infection can activate inflammatory pathways, therefore AP itself is not an indication for AB therapy [16,17]. Notably, current guidelines do not recommend prophylactic AB therapy for the prevention of infectious complications in AP (IAP/APA guideline, Grade 1B) [18], (American College of Gastroenterology, strong recommendation, moderate quality of evidence) [19]. However, in cases of proven source of infection empiric administration of ABs is justified [20].

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