Abstract
OBJECTIVE: To investigate the effect of short term energy restriction combined with physical activity on serum concentrations of Interleukin-6 (IL-6) in obese children and adolescents.
DESIGN: Longitudinal intervention study of 3.8–5 MJ daily with exercise.
SUBJECTS: Forty-nine white obese children and adolescents (31 girls, age 11.9±1.8 y; 18 boys, age 11.6±1.7 y).
MEASUREMENTS: Indexes of obesity, IL-6, leptin, estradiol, systolic and diastolic blood pressure, heart rate at baseline and after 3 weeks.
RESULTS: All determined parameters decreased significiantly during the 3 week program (IL-6: 3.9±4.7 vs 2.0±2.2 pg/ml; P<0.05). Body mass index (BMI) fat mass, percentage fat mass (indexes of obesity), and leptin were not related to IL-6 before the program. In contrast, IL-6 concentrations correlated significantly with indexes of obesity and leptin after weight loss. IL-6 concentrations did not correlate with estradiol, systolic and diastolic blood pressure, and heart rate. Changes in IL-6 concentrations correlated significantly with changes in BMI (r=0.25, P<0.05).
CONCLUSION: An improved body composition induced by restriction of energy intake and increase in physical activity is associated with more favorable serum concentrations of IL-6 in obese children and adolescents.
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References
Must A, Strauss RS . Risks and consequences of childhood and adolescent obesity Int J Obes Relat Metab Disord 1999 23: (Suppl 2): S2–S11.
Gallistl S, Sudi K, Mangge H, Erwa W, Borkenstein M . Insulin is an independent correlate of plasma homocysteine levels in obese children and adolescents Diabetes Care 2000 23: 1348–1352.
Gallistl S, Sudi KM, Borkenstein M, Troebinger M, Weinhandl G, Muntean W . Determinants of haemostatic risk factors for coronary heart disease in obese children and adolescents Int J Obes Relat Metab Disord 2000 24: 1459–1464.
Sudi KM, Gallistl S, Weinhandl G, Muntean W, Borkenstein MH . Relationship between plasminogen activator inhibitor-1-antigen, leptin, and fat mass in obese children and adolescents Metabolism 2000 49: 890–895.
Gallistl S, Sudi KM, Borkenstein M, Weinhandl G, Zotter H, Muntean W . Correlation between cholesterol, soluble P-selection, and D-dimer in obese children and adolescents Blood Coagul Fibrinol 2000 11: 755–760.
Yudkin JS . Abnormalities of coagulation and fibrinolysis in insulin resistance. Evidence for a common antecedent? Diabetes Care 1999 22: C25–30.
Yudkin JS, Kumari M, Humphries SE, Mohamed-Ali V . Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link? Atherosclerosis 1999 148: 209–214.
Fernandez-Real JM, Broch M, Vendrell J, Richart C, Ricart W . Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects J Clin Endocrinol Metab 2000 85: 1334–1339.
Ridker PM, Rifai N, Stampfer MJ, Hennekens CH . Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men Circulation 2000 101: 1767–1772.
Fried SK, Bunkin DA, Greenberg AS . Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid J Clin Endocrinol Metab 1998 83: 847–850.
Mohamed-Ali-V, Goodrick S, Rawesh A et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo J Clin Endocrinol Metab 1997 82: 4196–4200.
Wood PD, Stefanick ML, Dreon DM et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise New Engl J Med 1988 319: 1173–1179.
Gallistl S, Sudi KM, Cvirn G, Muntean W, Borkenstein M . Effects of short-term energy restriction and physical training on haemostatic risk factors for coronary heart disease in obese children and adolescents Int J Obes Relat Metab Disord 2001 25: 521–532.
Gutin B, Owens S, Slavens G, Riggs S, Treiber F . Effect of physical training on heart-period variability in obese children J Pediatr 1997 130: 938–943.
Papanicolaou DA, Petrides JS, Tsigos C et al. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines Am J Physiol 1996 271: E601–E605.
Girasole G, Jilka RL, Passeri G et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens J Clin Invest 1992 89: 883–891.
Lonnqvist F, Arner P, Nordfors L, Schalling M . Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nature Med 1995 1: 950–953.
Reiterer EE, Sudi KM, Mayer A et al. Changes in leptin, insulin and body composition in obese children during a weight reduction program J Pediatr Endocrinol Metab 1999 12: 853–862.
Must A, Dallal GE, Dietz WH . Reference data for obesity: 85th and 95th percentiles of body mass index (wt/ht2) and triceps skinfold thickness Am J Clin Nutr 1991 53: 839–846.
Schwingshandl J, Borkenstein M . Changes in lean body mass in obese children during a weight reduction program: effect on short term and long term outcome Int J Obes Relat Metab Disord 1995 19: 752–755.
Schaefer F, Georgi M, Zieger A, Scharer K . Usefulness of bioelectric impedance and skinfold measurements in predicting fat-free mass derived from total body potassium in children Pediatr Res 1994 35: 617–624.
Bastard JP, Jardel C, Bruckert E et al. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss J Clin Endocrinol Metab 2000 85: 3338–3342.
Mohamed Ali V, Pinkney JH, Coppack SW . Adipose tissue as an endocrine and paracrine organ Int J Obes Relat Metab Disord 1998 22: 1145–1158.
Longcope C, Baker R, Johnston CC Jr . Androgen and estrogen metabolism: relationship to obesity Metabolism 1986 35: 235–237.
Straub RH, Hense HW, Andus T, Scholmerich J, Riegger GA, Schunkert H . Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study J Clin Endocrinol Metab 2000 85: 1340–1344.
Akira S . IL-6-regulated transcription factors Int J Biochem Cell Biol 1997 29: 1401–1418.
Pidlich J, Pfeffel F, Zwiauer K, Schneider B, Schmidinger H . The effect of weight reduction on the surface electrocardiogram: a prospective trial in obese children and adolescents Int J Obes Relat Metab Disord 1997 21: 1018–1023.
Figueroa Colon R, Franklin FA, Lee JY, von Almen TK, Suskind RM . Feasibility of a clinic-based hypocaloric dietary intervention implemented in a school setting for obese children Obes Res 1996 4: 419–429.
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Gallistl, S., Sudi, K., Aigner, R. et al. Changes in serum interleukin-6 concentrations in obese children and adolescents during a weight reduction program. Int J Obes 25, 1640–1643 (2001). https://doi.org/10.1038/sj.ijo.0801808
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DOI: https://doi.org/10.1038/sj.ijo.0801808
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