Elsevier

Respiratory Medicine

Volume 101, Issue 2, February 2007, Pages 246-253
Respiratory Medicine

Breath-holding test in subjects with near-fatal asthma. A new index for dyspnea perception

https://doi.org/10.1016/j.rmed.2006.05.013Get rights and content
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Summary

Rationale

Identification of asthmatic subjects with low perception of dyspnea (POD) that are at higher risk of hospitalization, near-fatal and fatal asthma could improve their management.

Objective

Create a simple procedure that facilitate the recognition of low POD.

Methods

We enrolled near fatal asthma (NFA) subjects and a wide spectrum of non-NFA subjects. Each subject was asked to stop breathing at end-expiration. Dyspnea was assesssed by a modified Borg scale. To design the new index, we combined the Borg score at the end of the voluntary breath-holding maneuver with the airway limitation. The equation was as follows: FEV1/FVC%/(breath-holding time in seconds/final Borg score minus basal Borg score).

Results

Eleven NFA subjects (4 females) aged 21–73 yr and 55 non-NFA (14 severe, 18 moderate and 23 mild asthmatic subjects) completed the study. The threshold value of the index that could predict POD is <12. The mean (±sd) of the new index perception was significantly lower in NFA group (n=11; 5.21±3.59; vs. n=55; 13.67±11.08; P=0.006). This threshold value had 100% sensitivity and it best discriminated between mild and NFA groups. The negative likelihood ratio (when the index ⩾12) was zero. A result ⩾12 represented an almost null probability of poor POD.

Conclusion

The breath-holding test is simple and rapid. Its negative likelihood ratio was zero. Accordingly, a test result of 12 or greater might exclude the probability of poor perception of dyspnea in subjects with stable asthma.

Keywords

Asthma
Near-fatal asthma
Dyspnea
Perception

Cited by (0)

This study has been presented as an abstract at the Annual Congress of Argentinean Respiratory Medicine Association in Mendoza, Argentina, 8–11 October 2005.