Review ArticleThe statistical significance of randomized controlled trial results is frequently fragile: a case for a Fragility Index☆,
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Keywords
Randomized controlled trials
Research methodology
Lost to follow-up
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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
Conflict of interest: The authors have no conflicts of interest to declare. M.W. is supported by a New Investigator Award from the Kidney Research Scientist Core Education National Training (KRESCENT) Program. P.J.D. is supported by a Heart and Stroke Foundation of Ontario Career Investigator Award.
Ethical approval was not required for this study.
Funding: No funding was received for the conduct of this study and no sponsor was required.
Copyright © 2014 The Authors. Published by Elsevier Inc.