Clinical research: atrial fibrillation
The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study: Approaches to control rate in atrial fibrillation

https://doi.org/10.1016/j.jacc.2003.11.032Get rights and content
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Abstract

Objectives

We sought to evaluate approaches used to control rate, the effectiveness of rate control, and switches from one drug class to another in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) study.

Background

The AFFIRM study showed that atrial fibrillation (AF) can be treated effectively with rate control and anticoagulation, but drug efficacy to control rate remains uncertain.

Methods

Patients (n = 2,027) randomized to rate control in the AFFIRM study were given rate-controlling drugs by their treating physicians. Standardized rate-control efficacy criteria developed a priori included resting heart rate and 6-min walk tests and/or ambulatory electrocardiographic results.

Results

Average follow-up was 3.5 ± 1.3 years. Initial treatment included a beta-adrenergic blocker (beta-blocker) alone in 24%, a calcium channel blocker alone in 17%, digoxin alone in 16%, a beta-blocker and digoxin in 14%, or a calcium channel blocker and digoxin in 14% of patients. Overall rate control was achieved in 70% of patients given beta-blockers as the first drug (with or without digoxin), 54% with calcium channel blockers (with or without digoxin), and 58% with digoxin alone. Adequate overall rate control was achieved in 58% of patients with the first drug or combination. Multivariate analysis revealed an association between first drug class and several clinical variables. There were more changes to beta-blockers than to the other two-drug classes (p < 0.0001).

Conclusions

Rate control in AF is possible in the majority of patients with AF. Beta-blockers were the most effective drugs. To achieve the goal of adequate rate control in all patients, frequent medication changes and drug combinations were needed.

Abbreviations

AF
atrial fibrillation
AFFIRM
Atrial Fibrillation Follow-up Investigation of Rhythm Management study
AV
atrioventricular
HF
heart failure
HR
heart rate
MI
myocardial infarction
SR
sinus rhythm

Cited by (0)

This study was supported by the National Heart, Lung, and Blood Institute (contract N01-HC-55139), National Institutes of Health, Bethesda, Maryland. Mel Scheinman, MD, acted as Guest Editor for this paper.

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The AFFIRM investigators and their affiliations are listed in reference 32.