Dermatology grand rounds at the NIHNew facial papules in a 66-year-old woman with bladder cancer
Section snippets
History
A 66-year-old woman from India was referred to the Dermatology Consultation Service at the National Institutes of Health for evaluation of multiple small, skin-colored papules on her forehead. She was undergoing follow-up after achieving a near pathologic complete response to neoadjuvant chemotherapy with dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy followed by a radical cystectomy and ileal conduit formation for muscle-invasive urothelial bladder carcinoma. The
Discussion
MTS is a variant of Lynch syndrome, or hereditary nonpolyposis colorectal cancer, a hereditary cancer syndrome with increased risk of colorectal and extracolonic malignancies. MTS is distinguished by the development of at least 1 cutaneous sebaceous neoplasm (sebaceous adenoma, sebaceous epithelioma, sebaceous carcinoma) or multiple keratoacanthomas, in addition to at least 1 visceral neoplasm.1, 2, 3, 4 MTS-associated skin lesions are seen in approximately 9% of individuals with Lynch syndrome.
References (24)
- et al.
Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome
Am J Med
(1991) - et al.
Muir-Torre syndrome: case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature
J Am Acad Dermatol
(1999) - et al.
An update of HNPCC (Lynch syndrome)
Cancer Genet Cytogenet
(1997) - et al.
Behavior of urothelial carcinoma with respect to anatomical location
J Urol
(2007) - et al.
Muir-Torre syndrome
Lancet Oncol
(2005) - et al.
The Muir-Torre syndrome: a 25-year retrospect
J Am Acad Dermatol
(1995) - et al.
Diagnosis and management of hereditary colon cancer
Gastroenterol Clin North Am
(2002) Immunohistochemistry versus microsatellite instability testing for screening colorectal cancer patients at risk for hereditary nonpolyposis colorectal cancer syndrome, part I: the utility of immunohistochemistry
J Mol Diagn
(2008)- et al.
Multiple primary carcinomata of the colon, duodenum, and larynx associated with kerato-acanthomata of the face
Br J Surg
(1967) Multiple sebaceous tumors
Arch Dermatol
(1968)
Muir-Torre syndrome: report of a case and reevaluation of the dermatopathologic features
Cancer
The frequency of Muir-Torre syndrome among Lynch syndrome families
J Natl Cancer Inst
Cited by (3)
Muir'torre syndrome
2016, CMAJMultiple asymptomatic papules on the face and thorax
2017, JDDG - Journal of the German Society of DermatologyRapidly growing, painful nodule on the upper cutaneous lip
2015, JAMA Dermatology
This research was supported by the Intramural Program of National Institutes of Health (NIH), Center for Cancer Research, National Cancer Institute, and the NIH Medical Research Scholars Program, a public-private partnership supported jointly by the National Institutes of Health and generous contributions to the Foundation for the NIH from Pfizer Inc, the Doris Duke Charitable Foundation, the Alexandria Real Estate Equities Inc and Mr and Mrs Joel S. Marcus, and the Howard Hughes Medical Institute, as well as other private donors.
Conflicts of interest: None declared.
Reprints not available from the authors.