Original ArticleInteractions Between Life Stressors and Susceptibility Genes (5-HTTLPR and BDNF) on Depression in Korean Elders
Section snippets
Sample and Measurements
This analysis was carried out on data from a prospective community-based study of late-life psychiatric morbidity carried out in Kwangju, South Korea from 2001 to 2003, in collaboration with the 10/66 International Research Program on Dementia in Developing Countries (Prince et al. 2003). All participants gave written formal informed consent at each examination. This study was approved by the Chonnam National University Hospital Institutional Review Board.
Cross-sectional data were analyzed from
Results
Of 732 participants at baseline, case-level depression was present in 101 (13.8%). Frequencies of SLEs and 5-HTTLPR/BDNF genotypes in the sample are displayed in the first column of Table 1. These are compared between those with and without depression in the second through fifth columns of Table 1. Depression was significantly associated with increased numbers of SLEs. Although associations between depression and the two genotypes were in the directions anticipated, these were not significant.
Discussion
The principal findings of this study of community elders were as follows: 1) previous findings of effect modification between 5-HTTLPR genotype and SLEs on risk of depression were confirmed; 2) similar effect modification between BDNF val66met genotype and SLEs on risk of depression was identified; and 3) three-way effect modification between these two genotypes and SLEs on risk of depression was found. These findings were largely confirmed when the analysis was repeated in a follow-up study of
References (45)
Depression in the elderly
Lancet
(2005)- et al.
The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Cell
(2003) - et al.
Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children
Biol Psychiatry
(2006) - et al.
Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer’s disease in an older Korean population
Neurobiol Aging
(2004) - et al.
No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
Biol Psychiatry
(2004) - et al.
Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture
Am J Geriatr Psychiatry
(2005) The genetics of depression: A review
Biol Psychiatry
(2006)- et al.
Dementia diagnosis in developing countries: A cross-cultural validation study
Lancet
(2003) - et al.
Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder
Biol Psychiatry
(2006) - et al.
Early family environment, current adversity, the serotonin transporter promoter polymorphism, and depressive symptomatology
Biol Psychiatry
(2006)
Acute stress decreases serotonin transporter mRNA in the raphe pontis but not in other raphe nuclei of the rat
Neurosci Lett
BDNF in schizophrenia, depression and corresponding animal models
Mol Psychiatry
A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: IAffective disorders
Mol Psychiatry
Origins of depression in later life
Psychol Med
The list of threatening experiences: A subset of 12 life events categories with considerable long-term contextual threat
Psychol Med
Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene
Science
A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT
Psychol Med
A molecular and cellular theory of depression
Arch Gen Psychiatry
Improved method for detecting the long and short promoter alleles of the serotonin transporter gene HTT (SLC6A4)
Psychiatr Genet
Gene-environment interaction analysis of serotonin system markers with adolescent depression
Mol Psychiatry
Meta-analysis of studies of ventricular enlargement and cortical sulcal prominence in mood disorders
Arch Gen Psychiatry
Do the genetic or environmental determinants of anxiety and depression change with age?A longitudinal study of Australian twins
Twin Res
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