Physical findings
Muehrcke's Lines

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References (5)

  • R. Muehrcke

    The finger-nails in chronic hypoalbuminaemia: a new physical sign

    Br Med J

    (1956)
  • K. Wolff et al.

    Fitzpatrick's Color Atlas & Synopsis of Clinical Dermatology

    (2009)
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Cited by (19)

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    Other dermatologic diseases in the differential include atopic dermatitis, immunodeficiencies, and Langerhans cell histiocytosis.21 Nail findings associated with protein deficiency include dystrophy and Muehrcke’s lines.33,34 Muehrcke’s lines are classically associated with hypoalbuminemia.

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    The first association described and one of the main causes of Muehrcke’s lines is hypoalbuminemia (albumin <2.2 g/dL). Typically, Muehrcke’s lines disappear when the albumin levels return to normal and comes back if they decrease again.47,48 However, we can see Muehrcke’s lines in patients with normal albuminemia48 (Box 7).3,20,41,48

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    Therefore, no change in position occurs as the nail grows. It has also been observed in cases of cirrhosis, malnutrition and chemotherapy use.52 Lindsay nails (half and half).

  • Nail disorders as signs of pediatric systemic disease

    2012, Current Problems in Pediatric and Adolescent Health Care
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    Some authors believe with arsenic poisoning, Mee's lines represent arsenic deposition within the nail plate. Muehrcke's lines appear as paired narrow white transverse lines that present parallel to the lunula and disappear when pressure is applied to the nail plate.26 ( Fig 4).

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Thomas J. Marrie, MD, Section Editor

Funding: None.

Conflict of Interest: None of the authors have any conflicts of interest associated with the work presented in this manuscript.

Authorship: All authors had access to the data and played a role in writing this manuscript.

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