ReviewPrevalence of Vitamin D Deficiency in Patients With Acute Myocardial Infarction
Section snippets
Methods
We studied subjects enrolled in TRIUMPH. This registry collected information on patients admitted for AMI through chart abstraction, detailed patient interviews, as well as serum samples at 24 United States hospitals from April 11, 2005, to December 31, 2008. Inclusion criteria were very similar to TRIUMPH's predecessor, the Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER),6 and included patients aged ≥18 years with biomarker evidence of myocardial injury
Results
During the enrollment period of June 1 to December 31, 2008, 239 patients from 20 of the 24 TRIUMPH sites consented to baseline blood work and had 25(OH)D levels assessed via the DiaSorin radioimmunoassay method. The total population mean age was 57.6 ± 11.4 years, and 73.2% of the enrolled subjects were men (Table 2).
No significant heterogeneity was observed among age or gender subgroups (Table 2), but vitamin D deficiency was more commonly seen in non-Caucasian patients and those with lower
Discussion
This study describes the vitamin D status in post-AMI patients from a diverse population enrolled from across the United States from 20 separate sites, including academic and private institutions. Our findings of an extraordinarily high prevalence of vitamin D deficiency or insufficiency (96%) in the patients admitted for AMI are consistent with data associating CV disease and many of its risk factors with 25(OH)D deficiency.4 In addition to the findings of a high prevalence of 25(OH)D
Acknowledgment
We wish to thank Lori J. Wilson for her help in the preparation of this report.
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Vitamin D and cardiovascular diseases
2024, Advances in Food and Nutrition ResearchVitamin D deficiency is associated with impaired reperfusion in STEMI patients undergoing primary percutaneous coronary intervention
2021, Vascular PharmacologyCitation Excerpt :Vitamin D deficiency has been previously associated with the prevalence and extent of coronary artery disease, increased platelet reactivity and an enhanced inflammatory response favouring a pro-thrombotic milieu, that could account for the higher occurrence of myocardial infarction in case of inadequate levels. In effect, lower levels of 25(OH)D have been reported in patients with STEMI: a multicenter study performed in 239 ACS patients showed that 96% of them had vitamin D levels <30 ng/mL at hospital presentation [31] and in Ng et al. [32] 74% of AMI patients had low vitamin D levels, of whom 36% had a severe deficiency. Moreover, Safaie et al. reported that STEMI presentation was more common among patients with acute coronary syndrome in case of lower vitamin D levels [33].
Vitamin D and cardiovascular health
2021, Clinical NutritionThe regulation of FGF23 production in bone and outside of bone
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2020, Clinical Epidemiology and Global HealthCitation Excerpt :In addition, epidemiological studies have linked low serum levels of 25-(OH)D, with a range of medical conditions, including cardiovascular diseases.7–12 In particular, low levels of vitamin D have been associated with acute myocardial infarction (MI).13,14 There even is evidence that lower vitamin D levels are linked to increased mortality.15
NIH funding support of the TRIUMPH registry was through the National Heart, Lung and Blood Institute (P50 HL077113).