Clinical investigations: acute ischemic heart diseaseResting heart rate and cause-specific death in a 16.5-year cohort study of the Japanese general population☆
Section snippets
Populations
A total of 10,546 community dwellers (4640 men and 5906 women), ≥30 years of age in 300 randomly selected districts, participated in the survey; they were followed until November 15 in 1998. The current study extended the follow-up period of NIPPONDATA80 study, the details of which have previously been reported.12, 13, 14 Of the 10,546 participants, 1746 were excluded for the following reasons: past history of coronary heart disease or stroke (n = 280), missing information at baseline survey (n
Results
Table Ishows age-adjusted means or prevalences in the baseline characteristics of all participants by quartile of resting HR. There were significant differences in mean values for systolic blood pressure, diastolic blood pressure, pulse pressure, and serum glucose; they were higher in higher HR quartiles in both sexes. Mean values of BMI for men and albumin for women were also higher in higher quartiles of resting HR. Prevalence of antihypertensive agents users for women was lower in higher
Discussion
To our knowledge, few previous studies have examined the relation between resting HR and long-term death in Japanese living in Japan22, 23 (and Naito Y, et al, abstract in the Third International Conference of Preventive Cardiology, Oslo, 1993). However, these prior studies did not include age-specific analysis and were only limited to men. As in Western populations, higher HR was an independent predictor of all-cause death for middle-aged men and women in Japan. Resting HR also showed a
Acknowledgements
We thank Misao Ohara, Department of Health Science, Shiga University of Medical Science, for excellent clerical support in this research.
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2017, Nutrition, Metabolism and Cardiovascular DiseasesCitation Excerpt :Although the test for nonlinearity was significant, pnonlinearity < 0.0001, the association was approximately linear (Fig. 6b, Supplementary Table 10). Fifty nine prospective studies (48 risk estimates, 48 publications) [3,7,9–13,16,17,19,20,28,31,32,36–38,40–43,46–49,53–56,59,61–68,70–73,78,80,98,100–102] were included in the analysis of resting heart rate and all-cause mortality and included >134,183 deaths among 1,810,695 participants (Supplementary Table 9). The summary RR for a 10 beat per minute increase in resting heart rate was 1.17 (95% CI: 1.14–1.19, I2 = 94.0%, pheterogeneity < 0.0001) for all-cause mortality (Fig. 7a).
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Supported by the Research Grant for Cardiovascular Diseases (7A-2) from the ministry of Health and Welfare, Japan, and a Health and Labor Sciences Research Grant from the Ministry of Health, Labor and Welfare, Japan (Comprehensive Research on Aging and Health: H11-Chouju-046, H14-Chouju-003).