ReviewThe ins and outs of mitochondrial dysfunction in NASH
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Nitro-fatty acids as novel Virgin olive oil quality markers
2023, Journal of Food Composition and AnalysisOlfactomedin 4 deletion exacerbates nonalcoholic fatty liver disease through P62-dependent mitophagy in mice
2023, Metabolism: Clinical and ExperimentalAggravation of hepatic lipidosis in red-footed tortoise Chelonoidis carbonaria with age is associated with alterations in liver mitochondria
2022, Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular BiologyCitation Excerpt :Possible mechanisms leading to reduced mitochondrial activity in NASH are associated with damage promoted by high levels of reactive oxygen and nitrogen species. Other factors that influence mitochondrial activity in NAFLD are impaired mitochondrial dynamics and mitophagy, overproduction of TNF-α and interferons, Ca2+ overload, disruption of insulin signal and lipotoxicity (Fromenty et al., 2004; Shum et al., 2020). MPT is the phenomenon of a non-selective channel opening in the inner mitochondrial membrane, that allows the passage of matrix components below 1.5 kDa, and the colloidosmotic effect of water influx, leading to mitochondrial swelling and loss of membrane potential resulting in bioenergetics dysfunction, cellular injury and apoptosis or necrosis (Crompton, 1999; Gunter and Pfeiffer, 1990; Haworth and Hunter, 2000; Vercesi et al., 2018; Zoratti and Szabò, 1995).
Pancreastatin induces hepatic steatosis in type 2 diabetes by impeding mitochondrial functioning
2021, Life SciencesCitation Excerpt :On top of that, oxidative stress or reactive oxygen species (ROS) in cells or tissues deregulate mitochondrial biogenesis and membrane potential, which culminates in altered mitochondrial functioning and cellular apoptosis [12]. To support this, Fromenty et al. unveiled that, regardless of the initial cause of NASH, abnormal mitochondrial functioning, especially altered respiratory complex activity, plays a paramount important role in the pathophysiology of NASH [13]. Subsequently, dysregulated respiratory complex activity enhances mitochondrial ROS (mtROS); thereby, mitochondrial DNA (mtDNA) damage and structural abnormalities [14].
Olive oil-derived nitro-fatty acids: protection of mitochondrial function in non-alcoholic fatty liver disease
2021, Journal of Nutritional Biochemistry