How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action
Reference (29)
- et al.
Zinc (II) in saliva: determination of concentrations produced by several different formulations of zinc gluconate lozenges containing common excipients
J Pharm Sci
(1992) - et al.
J Biol Chem
(1989) - et al.
A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses
Cell
(1989) - et al.
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus
Cell
(1990) - et al.
Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study
Antimicrob Agents Chemother
(1984) The common cold
J Infect Dis
(1984)- et al.
Two randomized controlled trials of zinc gluconate lozenge therapy of experimentally induced rhinovirus colds
Antimicrob Agents Chemother
(1987) - et al.
Failure of effervescent zinc acetate lozenges to alter the course of upper respiratory tract infections in Australian adults
Antimicrob Agents Chemother
(1987) - et al.
Failure of zinc gluconate in treatment of acute upper respiratory tract infections
Antimicrob Agents Chemother
(1989) Zinc for the common cold
Antimicrob Agents Chemother
(1988)
Zinc gluconate and the common cold: a controlled clinical study
J Int Med Res
Zinc ions inhibit replication of rhinoviruses
Nature
Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides
J Virol
Cited by (74)
Asymmetrically substituted 5,5′′-diaryl-2,2′:6′,2′′-terpyridines as efficient fluorescence “turn-on” probes for Zn<sup>2+</sup> in food/cosmetic samples and human urine
2021, Journal of Photochemistry and Photobiology A: ChemistryCitation Excerpt :In the course of numerous experiments, it was found that lozenges containing zinc salts such as gluconate and acetate are the most optimal for the treatment of colds, because these salts release the maximum concentration of zinc in the form of a free cation, which has a therapeutic effect [65–72]. The presence of zinc ion binding agents, such as tartaric and citric acids [66,67,73], hydrogenated palm kernel and cotton seed oils [74] were reported to eliminate the therapeutic effect. Upon taking zinc-containing lozenges the blood plasma became saturated with zinc, while its excess of Zn2+ excretes with the urine [75].
Lines of Treatment of COVID-19 Infection
2021, Covid-19 Infection and PregnancyPotential role of zinc supplementation in prophylaxis and treatment of COVID-19
2020, Medical HypothesesRapid review protocol: Zinc for the prevention or treatment of COVID-19 and other coronavirus-related respiratory tract infections
2020, Integrative Medicine ResearchCitation Excerpt :Zinc may also modify the host's response to an infection as it is an essential co-factor element with a broad range of functions in the body. Many of the beneficial effects of zinc appear to take place at the cell membrane.8,21,22 Zinc (Zn2+) reduces the permeability of the cell membrane without penetration into or damage to the cell.
Studies on picornaviral proteases and their inhibitors
2017, Viral Proteases and Their Inhibitors