Letters to the EditorNew variant of Creutzfeldt-Jakob disease in a 26-year-old French man
References (3)
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A new variant of Creutzfeldt-Jakob disease in the UK
Lancet
(1996)
Cited by (225)
Variant Creutzfeldt–Jakob disease
2018, Handbook of Clinical NeurologyCitation Excerpt :The clinical and neuropathologic data of the 10 first patients with vCJD were published in April 1996 by the five countries of the EuroCJD group using similar methodology as in epidemiologic studies (Will et al., 1996). Shortly after, a case of vCJD was reported in France (Chazot et al., 1996). Beyond the strong epidemiologic argument – occurrence of a new human TSE in the most affected country by BSE – the link between BSE and vCJD was enhanced by biologic arguments: (1) observation, in the brains of macaques intracerebrally inoculated with the agent of BSE, of florid plaques, neuropathologic stigma of vCJD (Lasmezas et al., 1996); (2) identical migration on Western blot (type 4 or 2B) of disease-related prion protein from vCJD and BSE cases (Collinge et al., 1996); and (3) the same duration of incubation and identical histologic profile in mice inoculated with homogenates of brains of patients dead from vCJD and cattle affected with BSE in favor of a unique strain responsible for both diseases (Bruce et al., 1997).
Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases)
2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious DiseasesInfectious prion diseases in humans: Cannibalism, iatrogenicity and zoonoses
2014, Infection, Genetics and EvolutionCitation Excerpt :Variant CJD was first reported in 1996 in a short series of unusually young British patients with neuropathologically confirmed CJD (Will et al., 1996). A case was recognized in France soon after (Chazot et al., 1996) and, until now, a total of 229 probable and definite vCJD cases has been diagnosed worldwide, France being the most affected country after the UK. The phenotype of vCJD is not so far from kuru and is characterized by the frequent occurrence of psychiatric symptoms (depression, anxiety, apathy, withdrawal and delusions) and atypical pain in limbs or face at clinical onset.
Spread of classic BSE prions from the gut via the peripheral nervous system to the brain
2012, American Journal of PathologyEpidemiological surveillance of Creutzfeldt-Jakob in France
2009, Revue Neurologique