Rapid communicationDifferential sensitivity of C2-C12 striated muscle cells to lovastatin and pravastatin
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Genomics and precision medicine to direct statin use in the young
2019, Progress in Pediatric CardiologyCitation Excerpt :For instance, exposure to statin leads to a large range of myopathic events from mild (myalgias) to severe (rhabdomyolysis). In fact, available in vitro and in vivo data suggest that the degree of myopathic events may be statin-specific, meaning that the more hydrophilic statin agents (e.g. pravastatin, rosuvastatin) are of lower risk since there exists less passive diffusion into the skeletal myocyte [23–28]. Conversely, simvastatin, a more lipophilic statin agent with more potential to diffuse into the myocyte, was associated with impaired cardiorespiratory fitness in adult patients enrolled in an aerobic training exercise program [29].
Translational insight into statin-induced muscle toxicity: From cell culture to clinical studies
2014, Translational ResearchRed mold dioscorea decreases blood pressure when administered alone or with amlodipine and is a potentially safe functional food in SHR and WKY rats
2013, Journal of Functional FoodsCitation Excerpt :The causes of rhabdomyolysis include genetic metabolic myopathies, trauma, electrical injuries, exercise, infections, envenomation, hyperthermia, and adverse drug–drug interactions. The myotoxic effects of statins may result from the statin-induced interruption of glycoprotein synthesis, deficiency in chloride channel activation in the muscle membrane, and increased intracellular calcium concentration leading to impaired membrane function (Gadbut, Caruso, & Gabler, 1995). While CPK is normally abundant in the muscles, brain, thyroid, and red blood cells, significantly higher levels of CPK are associated with muscular diseases and conditions involving excessive use of muscles (Homsi, Barreiro, Orlando, & Higa, 1997).
Toxic Myopathies
2009, Clinical Neurotoxicology: Syndromes, Substances, Environments, Expert Consult - Online and PrintToxic myopathies
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