Alterations of anorectic cytokine levels from plasma and cerebrospinal fluid in idiopathic senile anorexia

doi:10.1016/0047-6374(93)90096-A

Mechanisms of Ageing and Development

Volume 72, Issue 2, 15 December 1993, Pages 145-153

https://doi.org/10.1016/0047-6374(93)90096-A Get rights and content

Abstract

Plasma and cerebrospinal fluid (CSF) concentrations of two well-known satiety cytokine peptides have been measured in elderly persons with idiopathic anorexia and normal weight healthy subjects in a similar age range. Plasma and CSF levels of tumor necrosis factor alfa (TNFα) and interleukin-1β (IL-1β) were assayed by commercially available kits. Elderly under-weight anorectic patients ancd significantly lower levels of TNFα but unchanged concentrations of IL-1β in both plasma and CSF when compared to controls. In addition to significantly lower levels of TNFα in CSF, we found a positive correlaton between the body mass index and CSF TNFα concentrations (r = 0.61, P < 0.05) in the anorectic group. CSF IL-1β concentrations showed a significant negative correlaton with plasma albumin levels in senile anorectics (r = −0.66, P < 0.05) but not in controls. On the basis of our findings, we conclude that a decrease in plasma and CSF TNFα concentrations could have beneficial effects for the primary anorexia of aging both at central level to offset anorexia and at peripheral sites decreasing tissue catabolism.

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Alterations of anorectic cytokine levels from plasma and cerebrospinal fluid in idiopathic senile anorexia

Abstract

Brain Res.

J. Psychosom. Res.

J. Biol. Chem.

Am. J. Med.

Brain Res. Bull.

J. Neuroimmunol.

Life Sci.

Molecular basis for bidirectional communication between the immune and neuroendocrine systems

Physiol. Rev.

An analysis of the pyrogen induced inhibition of gastric motility in sheep

J. Physiol.

Interleukin-1 affects glucose homeostasis

Am. J. Physiol.

Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor-α and TNF-α fragments

Am. J. Physiol.

Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice

J. Exp. Med.

The anorexia of the elderly

Ann. N.Y. Acad. Sci.

The assessment of the amount of fat in the human body from measurement of skinfold thickness

Br. J. Nutr.

A controlled trial of megestrol acetate on appetite, caloric intake, nutritional status, and other symptoms in patients with advanced cancer

Cancer