Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria☆
References (25)
- et al.
Experimental homocysteinemia in pigs: Comparison with studies in sixteen homocystinuric patients
Metabolism
(1982) - et al.
Homocystine theory of arteriosclerosis
Atherosclerosis
(1975) - et al.
Homocystinuria due to cystathionine synthase deficiency: Enzymatic and ultrastructural studies
J Pediatr
(1974) - et al.
Effects of oral contraceptives and obesity on carrier tests for phenylketonuria
Clin Chim Acta
(1973) - et al.
Deficiency of Vitamin B12-binding alpha globulin in two brothers
Blood
(1969) - et al.
Disorders of transsulfuration
Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis
Am J Pathol
(1969)- et al.
Morphologic studies in a patient with homocystinuria due to 5, 10-methylene-tetrahydrofolate reductase deficiency
Pediatr Res
(1976) - et al.
Vascular lesions in two patients with congenital homocystinuria due to different defects of remethylation
J Inher Metab Dis
(1980) - et al.
Homocystinemia. Vascular injury and arterial thrombosis
N Engl J Med
(1974)
Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis
J Clin Invest
Production of arteriosclerosis by homocysteinemia
Am J Pathol
Cited by (127)
Homocysteinemia and vascular disease: Where we stand in 2022
2022, Revista Portuguesa de CardiologiaLocal pharmacological induction of angiogenesis: Drugs for cells and cells as drugs
2019, Advanced Drug Delivery ReviewsCitation Excerpt :Ischemia onset is usually gradual, caused by changes in the vessel walls leading to stenosis, but can progress to dangerous levels (CLI, crescendo angina pectoris) and be suddenly aggravated by a blood clot that either rapidly forms at a wall lesion (thrombosis) and occludes the lumen or has formed there but is transported to another location in the vasculature where it finally occludes a vessel (embolus) [21,22]. On the microlevel, a diffuse obliteration process of small vessels and capillaries can lead to ischemia as well, triggered by metabolic aberrances such as hyperglycaemia in diabetes, but also homocystinuria and inflammatory conditions such as lupus erythematosus [23–25]. Damage of retinal capillaries, nerves and loss of filtration function of renal glomeruli are all manifestations of capillary injury [26–28].
Conformational status of cytochrome c upon N-homocysteinylation: Implications to cytochrome c release
2017, Archives of Biochemistry and BiophysicsCitation Excerpt :Thus, we conclude that loss of heme-Met80 interaction is responsible for the activation of peroxidase activity in HTL modified cyt c. In support of our observation, it has been demonstrated that disruption of cyt c heme coordination is responsible for mitochondrial injury during ischemia [41] which is also a common complication under homocysteinemic conditions [20,42–44]. Furthermore, in ischemic mouse model, the levels of cyt c homocysteinylation were shown to increase in brain [20].
Diagnosis of cystathionine beta-synthase deficiency by genetic analysis
2014, Journal of the Neurological SciencesCitation Excerpt :A controversial issue with regard to CBS deficiency is potential pathological consequences of being a heterozygous carrier of a CBS mutation [15-17]. This is important because an association between increased plasma homocysteine and cardiovascular disease has been reported [18-21]. To the best of our knowledge, we here report for the first time clinical findings and genetic analysis of Iranian patients affected with CBS deficiency.
Genotype-independent in vivo oxidative stress following a methionine loading test: Maximal platelet activation in subjects with early-onset thrombosis
2011, Thrombosis ResearchCitation Excerpt :Moderate hyperhomocysteinemia (HHcy), a common metabolic abnormality (5-10% of the general population), has been associated with an abnormally high risk of thrombotic events [1–5].
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Supported in part by grants to one of us (DELW) from the National Health and Medical Research Council of Australia and the Ramaciotti Foundations.