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Salmon calcitonin in the therapy of corticoid-induced osteoporosis

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Summary

There is uncertainty about the best treatment for steroid-induced osteoporosis. Thirty-six patients with steroid-dependent, chronic obstructive lung disease and associated steroid osteoporosis have been studied, of whom 18 were treated with salmon calcitonin and the other 18 served as controls. Treatment lasted for 6 months and consisted of 100 I.U. s.c. every other day.

In the controls there were significant decrements of 1.4% and 3.5%, respectively, in cortical and cortical and trabecular bone mineral content, whereas in subjects on calcitonin there were increments of 2.6% and 2.7%, respectively.

Additional evidence of positive effect of calcitonin was derived from the reduced incidence of new fractures occurring during the observation period. A significant reduction in back pain was a further consequence of the hormone therapy.

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References

  1. Cushing H (1932) The basophil adenomas of the pituitary body and their clinical manifestations (Pituitary Basophilism). Bull Johns Hopk Hosp 50: 137–142

    Google Scholar 

  2. Adinoff AD, Hollister JR (1983) Steroid-induced fractures and bone loss in patients with asthma. N Engl J Med 309: 265–268

    Article  PubMed  CAS  Google Scholar 

  3. Baylink DJ (1983) Glucocorticoid-induced osteoporosis. N Engl J Med 309: 306–308

    Article  PubMed  CAS  Google Scholar 

  4. Ringe JD (1983) Sekundäre Osteoporose bei Kortikoid-Langzeittherapie. Atemw Lungenkrankh 9: 54–56

    Google Scholar 

  5. Ringe JD, Steinhagen-Thiessen E (1984) Häufigkeit, Schweregrad und Manifestationsmuster der Osteoporose beim Cushing-Syndrom. Akt Endokr Stoffw 5: 191–195

    Google Scholar 

  6. Schaadt O, Bohr H, Thomsen AC (1981) Steroid-treatment and bone mineral content in peripheral and axial skeleton. Calcif Tissue Int 33 [Suppl]: 181

    Google Scholar 

  7. Dempster DW, Arlot MA, Meunier PJ (1983) Mean wall thickness and formation periods of trabecular bone packets in corticoid-induced osteoporosis. Calcif Tissue Int 35: 410–417

    Article  PubMed  CAS  Google Scholar 

  8. Ringe JD (1984) Glucocorticoid-induzierte Osteoporose. In: Fehm L, Köbberling H, Graupe K (eds) Glukokortikoide: Forschung und Therapie. Perimed, Erlangen

    Google Scholar 

  9. Ringe JD (1985) Nebennierenüberfunktion und Skelett. Therapiewoche 35: 5131–5140

    Google Scholar 

  10. Chesnut CH, Baylink DJ, Gruber HE, Ivey JL, Matthews M, Nelp WB, Sisom K, Taggart HM, Reynolds JC, Roos BA (1984) Synthetic salmon calcitonin in postmenopausal osteoporosis: Current concepts. In: Avioli LV, Dambacher MA (ed) Calcitonin: Das therapeutische Potential bei Osteoporose. Schattauer, Stuttgart New York

    Google Scholar 

  11. Cascio VL, Adami S, Avioli LV, Cominacini L, Galvanini G, Gennari C, Imbimbo B, Scuro LA (1982) Suppressive effect on chronic corticoid treatment on circulating calcitonin in man. Calcif Tissue Int 34: 309–311

    Article  Google Scholar 

  12. Cameron JR, Sorenson JA (1963) Measurement of bone mineral in vivo: An improved method. Science 142: 230–232

    PubMed  CAS  Google Scholar 

  13. Mazess RB (1979) Measurement of skeletal status by noninvasive methods. Calcif Tissue Int 28: 89–92

    Article  PubMed  CAS  Google Scholar 

  14. Ringe JD (1982) Die klinische Bedeutung der direkten Messung des Knochenmineralgehaltes. 125J-Photonenabsorptionsmessung an 1252 Fällen. Urban & Schwarzenberg, Wien München Baltimore

    Google Scholar 

  15. Ringe JD, Rehpenning W, Kuhlencordt F (1977) Physiologische Änderung des Mineralgehaltes von Radius und Ulna in Abhängigkeit von Lebensalter und Geschlecht. Fortschr Röntgenstr 126: 376–380

    Article  CAS  Google Scholar 

  16. Ringe JD, Rehpenning W, Steinhagen-Thiessen E (1985) Increasing skeletal involution in the elderly? Mech Ageing Dev 29: 83–88

    Article  PubMed  CAS  Google Scholar 

  17. Avioli LV (1982) Calcitonin therapy for bone disease and hypercalcemia. Arch Intern Med 142: 2076–2079

    Article  PubMed  CAS  Google Scholar 

  18. Chesnut CH, Baylink DJ, Ross BA, Gruber HE, Ivey JL, Matthews M, Nelp WP, Sisom K (1981) Calcitonin and post-menopausal osteoporosis. In: Pecile A (ed) Calcitonin 1980. Excerpta Medica, Amsterdam Oxford Princeton, pp 247–255

    Google Scholar 

  19. Milhaud G, Talbot JN, Coutris G (1975) Calcitonin treatment of post-menopausal osteoporosis. Evaluation of efficancy by principal components. Biomedicine 22: 223–232

    PubMed  CAS  Google Scholar 

  20. Rico Lenza H, Hernandez Diez ER, Nunez-Torron M, Torrubiano Aranguren J, Espinos Perez D (1985) Resultados, a largo plazo, del tratamiento de la osteoporosis posmenopausica con calcitonina y calcio. Med Clin (Barcelona) 84: 563–565

    CAS  Google Scholar 

  21. Wallach S, Cohn SH, Atkins HL, Ellis KJ, Kohberger R, Aloia JF, Zanzi I (1977) Effect of salmon calcitonin on skeletal mass in osteoporosis. Curr Ther Res 22: 556–572

    Google Scholar 

  22. Thompson JS, Palmieri GMA, Eliel LP, Crawford RJ (1972) The effect of porcine calcitonin on osteoporosis induced by adrenal cortical steroids. J Bone Joint Surg 54 A: 1490–1500

    Google Scholar 

  23. Pasero GP, Gennari C, Di Munno O, Agnusdei D, Montagnani M (1985) Prevention of glucocorticoid-induced osteopenia by calcitonin. In: Pecile A (ed) Calcitonin 1984. Elsevier Amsterdam, pp 315–323

    Google Scholar 

  24. Beaufort F, Gölles M (1984) Calcitonin beim skelettmetastasierten Mammakarzinom. Ergebnisse einer Pilotstudie. Onkologie 7: 137–140

    Article  PubMed  CAS  Google Scholar 

  25. Kleibel F, Schmidt G (1984) Salm-Calcitonin bei metastatischen Knochenschmerzen. Dtsch Med Wochenschr 109: 944–947

    PubMed  CAS  Google Scholar 

  26. Oricchio P, Pompei V, Mazzei L (1981) La calcitonina nel trattamento del dolore da osteolisi neoplastiche. G Ital Oncol 1: 235–240

    Google Scholar 

  27. Welzel D, Schmidt G, Kleibel F, Berressem P (1984) Calcitonin relieves pain in patients suffering from bone cancer. In: Pecile A (ed) Calcitonin 1984. Elsevier, Amsterdam, pp 435–447

    Google Scholar 

  28. Ringe JD, Steinhagen-Thiessen E (1984) Sekundäre Osteoporose bei Corticoidlangzeittherapie. Therapie und Prophylaxe. Arzneimitteltherapie 2: 59–62

    Google Scholar 

  29. Caniggia A, Gennari C (1973) Effect of 25-hydroxycholecalciferol (25-HCC) on intestinal absorption of 47-Ca in four cases of iatrogenic Cushing's syndrome. Helv Med Acta 37: 221–225

    PubMed  CAS  Google Scholar 

  30. Condon JR, Nassim JR, Dent CE, Hilb A (1978) Possible prevention and treatment of steroid-induced osteoporosis. Postgrad Med J 54: 249–252

    Article  PubMed  CAS  Google Scholar 

  31. Hahn TJ, Halstead LR, Teitelbaum SL (1979) Altered mineral metabolism in glucocorticoid-induced osteopenia. Effect of 25-hydroxyvitamin D administration. J Clin Invest 64: 655–665

    Article  PubMed  CAS  Google Scholar 

  32. Ringe JD (1985) Pathogenese und Therapie der Steroid-osteoporose. Sandorama 1: 9–13

    Google Scholar 

  33. Raue F, Ziegler R (1984) Calcitonin: Zum Rätsel des Escape-Phänomens. Aktuel Endorinol 5: 7–11

    Google Scholar 

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Authors and Affiliations

  1. Medical Clinic, Hamburg University, Hamburg, Federal Republic of Germany

    J. -D. Ringe

  2. Pharmacological Department, Regensburg University, Regensburg, Federal Republic of Germany

    D. Welzel

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  1. J. -D. Ringe
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  2. D. Welzel
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Ringe, J.D., Welzel, D. Salmon calcitonin in the therapy of corticoid-induced osteoporosis. Eur J Clin Pharmacol 33, 35–39 (1987). https://doi.org/10.1007/BF00610377

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  • DOI: https://doi.org/10.1007/BF00610377

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